Results 241 to 250 of about 71,097 (291)

Pharmacological Inhibition of EZH2 by GSK‐343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
In a mouse model of spinal cord injury, pharmacological inhibition of EZH2 with GSK‐343 reduces tissue damage and neuronal demyelination. GSK‐343 suppresses the EZH2/TRAF6/NF‐κB signaling pathway, leading to attenuation of neuroinflammation and innate immune activation. These effects promote early neuroprotection and improved locomotor recovery in vivo.
Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici, Bulzomì Maria, Ahmed Hasan, Antonio Catalfamo, Jia Yang, Marika Lanza, Alessia Filippone   +9 more
wiley   +1 more source

Diffuse Cutaneous Mastocytosis with Bullous Presentation: A Rare Case Report.

Indian J Dermatol
Mendiratta V, Bansal A, Singh S, Jain A.
europepmc   +1 more source

Design and Structural Transformations of Zinc(II) Knotted Cage Frameworks. [PDF]

Angew Chem Int Ed Engl
Yang Y, Hu SY, Ronson TK, Teeuwen PCP, Gaikwad S, Heard AW, Wales DJ, Nitschke JR.   +7 more
europepmc   +1 more source

In Vivo Evaluation of Hemiarthroplasty Bearing Materials Using Animal Models: A Scoping Review (Part II)

Journal of Orthopaedic Research, Volume 44, Issue 1, January 2026.
ABSTRACT Hemiarthroplasty is commonly used to treat damage localized to one side of a synovial joint, maximally preserving the patient's opposing healthy bone and cartilage; however, challenges remain due to accelerated wear of the cartilage articulating with the implant surface. This scoping review summarized investigations of hemiarthroplasty bearing
Landon M. Begin, Victoria P. Marino, Francesca De Vecchi, Douglas C. Moore, Markus A. Wimmer, Joseph J. Crisco   +5 more
wiley   +1 more source

Validation of an Endoscopic Landmark for Injection of Internal Branch of Superior Laryngeal Nerve

The Laryngoscope, Volume 136, Issue 1, Page 312-318, January 2026.
This study validates a transnasal endoscopic approach to target the internal branch of the superior laryngeal nerve (iSLN) via the piriform sinus. Cadaveric analysis showed this method enables precise localization with minimal variability, offering a promising technique for treating laryngeal sensory dysfunction.
Yuki Tanigami, David Hortobagyi, Andrew J. Bowen, Chelsea Kruse, Seth H. Dailey   +4 more
wiley   +1 more source

Optimizing a feasible protocol for acellular nerve allografts: An experimental study. [PDF]

Cell Tissue Bank
Camporro Fernández D, de Juan Marín M, Pevida M, Llames S, Argüelles Luís J, Meana Á.   +5 more
europepmc   +1 more source

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell‐Derived Extracellular Vesicles in Rheumatoid Arthritis

MedComm, Volume 7, Issue 1, January 2026.
CCR2 orchestrates preferential homing of GMSC‐derived extracellularvesicles to inflamed joints in rheumatoid arthritis. ABSTRACT The clinical utility of mesenchymal stem cells (MSCs) is often limited by pulmonary entrapment and poor systemic distribution, particularly in diseases constrained by physiological barriers such as rheumatoid arthritis (RA ...
Jingrong Chen, Xiao Guan, Wenbin Wu, Luyao Wu, Yan Liu, Donglan Zeng, Junlong Dang, Jun Zhao, Julie Wang, Jia Yuan, Xiaoli Fan, Yunfeng Pan, Nancy Olsen, Song Guo Zheng   +13 more
wiley   +1 more source

Endothelial senescence drives intrinsic skin aging via the neuroimmune CGRP-mast cell axis in mice. [PDF]

Commun Biol
Wicaksono SA, Ryanto GRT, Suzuki Y, Hara T, Ikeda K, Fukumoto T, Hirata KI, Otake H, Emoto N.   +8 more
europepmc   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source

Tissue-Specific Developmental Changes in Lignin Deposition in Model Plants. [PDF]

Physiol Plant
Zhu W, Barros J.
europepmc   +1 more source