Results 81 to 90 of about 51,076 (258)

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Optical Stimulation and Monitoring of the Peripheral Nervous System: Perspectives and Challenges Toward Clinical Translation

Laser &Photonics Reviews, EarlyView.
Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo, Sarassunta Ucci, Anna Aliberti, Patrizio Vaiano, Alessia La Rocca, Francesca Angelone, Silvia Pascarella, Pellegrino Lippiello, Maria Concetta Miniaci, Giuseppe Prisco, Michela Russo, Francesco Amato, Deyanira Contartese, Milena Fini, Gianluca Giavaresi, Lucia Martini, Francesco Rosa, Cosimo Gentile, Emanuele Gruppioni, Armando Ricciardi, Andrea Cusano   +20 more
wiley   +1 more source

Predicting Mesoscopic Larmor Frequency Shifts in Ex Vivo Porcine Optic Nerve

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Larmor frequency shifts in white matter (WM) vary with fiber orientation due to anisotropic microstructure. Since clinical voxels are significantly larger than these microscopic frequency variations, the measured signal represents a bulk average of local shifts.
Anders Dyhr Sandgaard, André Pampel, Roland Müller, Niklas Wallstein, Toralf Mildner, Carsten Jäger, Markus Morawski, Aage Kristian Olsen Alstrup, Harald E. Möller, Sune Nørhøj Jespersen   +9 more
wiley   +1 more source

Revisiting the leaf anatomy of Hymenaea martiana: new insights from anatomical and histochemical techniques

Nordic Journal of Botany, EarlyView.
Hymenaea martiana, known as ‘jatobá', is used in folk medicine and has similarities with Hymenaea courbaril, making its recognition difficult. Although there are different pharmacological reports that attest to its bioactive potential, there are few studies with leaf extracts in H. martiana.
Catarina Silva Lima, João Victor da Costa Santos, João Gilberto Meza Ucella Filho, Josiane Silva Araújo   +3 more
wiley   +1 more source

Pneumocystis jirovecii in Respiratory Tract of Immunocompromised Patients: A Study in a Tertiary Care Center in Bangalore, South India

Journal of Medical Microbiology and Infectious Diseases
Introduction: Pneumocystis jirovecii pneumonia (PCP) remains a significant cause of pneumonia among immunocompromised individuals, despite a decline in prevalence with the advent of antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV ...
Pratibha Shamanna1*, Muralidharan Sethumadhavan2   +1 more
doaj   +1 more source

The effectiveness of PDT in the correction of inflammatory changes in periodontal tissues according to the experimental studies

Эндодонтия Today, 2020
In an experimental study the possibility of correction of inflammatory periodontal diseases by using such medications as Photoditazin gel 0.5%, Toluidine blue 1% solution, 1% solution of methylene blue, when using a laser that has the wavelength λ = 662 ...

doaj  

Photodynamic Inactivation of Bovine Coronavirus with the Photosensitizer Toluidine Blue O. [PDF]

Viruses, 2023
Zaharieva MM, Foka P, Karamichali E, Kroumov AD, Philipov S, Ilieva Y, Kim TC, Podlesniy P, Manasiev Y, Kussovski V, Georgopoulou U, Najdenski HM.   +11 more
europepmc   +1 more source

TP53 mutations orchestrate partial EMT states in oral squamous cell carcinoma: spatially resolved and in vitro preliminary insights into tumour plasticity

The Journal of Pathology, EarlyView.
Abstract TP53 is the most frequently mutated gene in oral squamous cell carcinoma (OSCC); however, its role in promoting epithelial–mesenchymal transition (EMT) and tumour progression remains unclear, particularly within the context of intra‐tumour heterogeneity.
Rana Alaaeldin Ibrahim, Hong Wan, Raju Kumar, Muy‐Teck Teh, Angray Kang, Emma Bailey, Hannah Cottom, Adrian Biddle, Inês Sequeira, Farida Fortune   +9 more
wiley   +1 more source