Results 141 to 150 of about 1,074 (253)

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

open access: yesArthritis &Rheumatology, Volume 78, Issue 5, Page 1045-1061, May 2026.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin   +15 more
wiley   +1 more source

Ceramidonines, Fused 3,9‐Diazaperylenes, and Related Compounds: From Synthesis to Physicochemical Properties and Evaluation as Inhibitors of PIM Kinases

open access: yesChemistryEurope, Volume 4, Issue 5, May 2026.
Ceramidonines, benzo‐fused 3,9‐diazaperylenes and related compounds were synthesized, and their properties studied. Substituted ceramidonines were synthesized by cyclization of 1‐(arylamino)anthraquinones under acidic conditions. These key intermediates were prepared either by copper‐promoted N‐arylation of 1‐aminoanthraquinone with iodoarenes or, more
Ahlem N. Khelf‐Maghraoui   +15 more
wiley   +1 more source

Comprehensive Evaluation of the Anti‐Inflammatory Activity of Ling‐Zhi‐8 (LZ‐8) In Vitro and a Rheumatoid Arthritis Animal Model

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
LZ‐8 reduced IL‐6 and COX‐2 in LPS‐stimulated macrophages, partly by inhibiting MyD88‐mediated JNK‐MAPK signaling. LZ‐8 reduced inflammation and swelling in the ankle and palm of the feet in the animal model. High‐dose LZ‐8 reduced synovial hyperplasia, and all doses protected articular cartilage.
Shao‐Wen Hung   +3 more
wiley   +1 more source

Five Years of Ublituximab in Multiple Sclerosis: ULTIMATE I and II Open-Label Extension Study.

open access: yesJAMA Neurol
Cree BAC   +14 more
europepmc   +1 more source

Arising amitraz and pyrethroids resistance mutations in the ectoparasitic Varroa destructor mite in Canada. [PDF]

open access: yesSci Rep
Bahreini R   +6 more
europepmc   +1 more source

Understanding the Influence of Modified Surfaces on Early Dynamics of Osseointegration by Histomorphometric Analysis: An In Vivo Study

open access: yesJournal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 5, May 2026.
ABSTRACT Rapid osseointegration remains a topic of interest in implant dentistry; however, the effects of modified surfaces during the early stages of osseointegration are not entirely elucidated. With that purpose, this study aimed to critically investigate early osseointegration parameters in cortical and trabecular bone through histological analysis
Hanna Aludden   +3 more
wiley   +1 more source

Tracking Aromatic Amines from Sources to Surface Waters. [PDF]

open access: yesEnviron Sci Technol Lett
Edebali Ö   +5 more
europepmc   +1 more source

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