Results 121 to 130 of about 1,074 (253)

Teriflunomide Concentrations in Cerebrospinal Fluid and Plasma in Patients with Multiple Sclerosis: A Pharmacokinetic Study. [PDF]

CNS Drugs, 2023
Lycke J, Farman H, Nordin A.
europepmc   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Long-term safety and efficacy of ponesimod in participants with relapsing multiple sclerosis: results from the phase 3 OPTIMUM 5-year long term extension study. [PDF]

J Neurol
Montalban X, Hohlfeld R, Pozzilli C, Freedman MS, Sprenger T, Fox RJ, Havrdova EK, Lublin F, Huang D, Raghavan N, Wong J, Vaclavkova A, Dukovski J, Linscheid P, Burcklen M, Kappos L.   +15 more
europepmc   +1 more source

The role of neutrophils in the pathophysiology of inflammatory bowel diseases

Periodontology 2000, EarlyView.
Abstract Objectives Inflammatory bowel disease (IBD) encompasses a spectrum of chronic disorders of the gastrointestinal tract, with a potential bidirectional relationship with periodontitis. Neutrophils are key regulators of immune‐inflammatory responses and play a major role in both diseases.
Joao Paulo Steffens, Ekin Yay‐Kus, Rafael Scaf de Molon, Viorelia Stoica, Peter Rimmer, Josefine Hirschfeld, Asif Jilani Iqbal, Tariq Iqbal, Iain Chapple   +8 more
wiley   +1 more source

Effectiveness of teriflunomide in patients with relapsing multiple sclerosis who switched from other disease-modifying therapies. [PDF]

Medicine (Baltimore)
Berkovich R, Greene N, Reddy SR, Chang E, Tarbox MH, Fadaee S, Quach C, Pyatkevich Y.   +7 more
europepmc   +1 more source

Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress

The Journal of Physiology, EarlyView.
Abstract figure legend Using genetically encoded sensors for NADPH and H2O2 in the living Drosophila nervous system, neuron‐specific PPP knockdown is shown to result in reduced neuronal NADPH levels and elevated neuronal H2O2 levels and oxidative stress.
Stephan Müller, Nina Surina, Andrés Köhler‐Solís, Ioannis Nellas, Astrid Fleige, Sebastian Görtz, Stefanie Schirmeier   +6 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, EarlyView.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Synergistic Effects of Amitraz and Dinotefuran on Honey Bee Health: Impacts on Survival, Gene Expression, and Hypopharyngeal Gland Morphology. [PDF]

Int J Mol Sci
Esmaeily M, Begna T, Jang H, Kwon S, Jung C.   +4 more
europepmc   +1 more source

Teriflunomide and Epstein-Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response. [PDF]

Front Immunol, 2023
Domínguez-Mozo MI, González-Suárez I, Villar LM, Costa-Frossard L, Villarrubia N, Aladro Y, Pilo B, Montalbán X, Comabella M, Casanova-Peño I, Martínez-Ginés ML, García-Domínguez JM, García-Martínez MÁ, Arroyo R, Álvarez-Lafuente R.   +14 more
europepmc   +1 more source

Intradiscal Cutibacterium acnes Sustains Modic Type 1‐Like Lesions Over Time in a Rat Lumbar Endplate Injury Model

JOR SPINE, Volume 9, Issue 2, June 2026.
Intradiscal C. acnes injection sustained MC1‐like lesions with persistent neutrophil sustenance in an etiology‐specific lumbar MC rat model. This suggests that patients with bacterial MC etiology may persist in painful MC1, highlighting C. acnes and neutrophils as potential targets to promote MC1‐to‐MC2 conversion and improve pain and disability ...
Irina Heggli, Alon Lai, Denise Iliff, Marco D. Burkhard, Niklas Koehne, Harsev Singh, Jonathan J. Huang, Alan C. Seifert, Damien Laudier, Noah Bonnheim, Levon Rodriguez, Timothy D. Jacobsen, James C. Iatridis   +12 more
wiley   +1 more source