Results 171 to 180 of about 1,061 (244)

Application of Intracellular Vesicles Surpass Extracellular Vesicles in Regenerative Repair of Inflammatory Bone Defects via the LAMA4‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Periodontitis‐induced inflammatory microenvironment compromises the function of periodontal ligament stem cells (PDLSCs) and significantly impedes the regeneration of periodontal tissues. Meanwhile, the clinical application of extracellular vesicles (EVs) is constrained by their low yield and high production costs.
Haotian Liu, Yu Wu, Qunyi Wang, Ting Zhang, Xin Tong, Fuhua Yan, Qian Zhang   +6 more
wiley   +1 more source

Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study. [PDF]

Chin Med J (Engl)
Quan C, Zhou H, Yang H, Jiao Z, Zhang M, Zhang B, Tan G, Bu B, Jin T, Li C, Xue Q, Dong H, Shi F, Qin X, Zhang X, Gao F, Zhang H, Wang J, Hu X, Chen Y, Liu J, Qiu W.   +21 more
europepmc   +1 more source

Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε‐caprolactone) Scaffolds Enhances Tendon‐to‐Bone Integration

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
ABSTRACT Tendon and ligament injuries often require surgery, with successful recovery, whether direct repair of a torn tendon to bone or reconstruction of ligaments, requiring effective tendon‐to‐bone integration. Unfortunately, re‐tear rates can be high, demonstrating the need for improved treatment strategies. The Hedgehog (Hh) pathway is critical to
Jonathan Marcelin, Rashad Madi, Timur B. Kamalitdinov, Xi Jiang, Dong Hwa Kim, Robert L. Mauck, Andrew F. Kuntz, Nathaniel A. Dyment   +7 more
wiley   +1 more source

Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
ABSTRACT Osteochondral injuries are common, painful, and lack natural healing abilities. Previous studies demonstrated that recombinant human amelogenin promotes osteochondral repair in rat knee injuries, including improved defect filling and formation of hyaline cartilage.
Omer Helwa‐Shalom, Hani Nevo, Tarek Nasrawy, Masha Galiner, Azraq Yusef, Keren Ben‐David, Shany Ivon Markowitz, Yechiel N. Gellman, Shaul Beyth, Hagit Sacks, Anat Blumenfeld, Amir Haze   +11 more
wiley   +1 more source

ApoJ regulates endothelial lipase activity and stability

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste, Simcha R. Singh, Ming J. Wu, Kellen Christina da Cruz Rodriguez, Young‐Bum Kim, Saskia B. Neher   +5 more
wiley   +1 more source

Clusterin deficiency is associated with a lack of response to teriflunomide in multiple sclerosis. [PDF]

Clin Transl Med
Malhotra S, Fissolo N, Rodríguez-Rivera C, Monreal E, Montpeyo M, Urcelay E, Triviño JC, Pérez-García MJ, Segura MF, Pappolla A, Río J, Vilaseca A, Fernández Velasco JI, Miguez A, Goicoechea C, Martinez-Vicente M, Villar LM, Montalban X, Comabella M.   +18 more
europepmc   +1 more source

FGF21‐Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

Aging Cell, Volume 25, Issue 4, April 2026.
FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu, Rui Ran, Qi‐qi Xie, Cong Zhang, Ya‐jun Chen, Peng Cheng, Ke‐Ping Wang, Hai‐hong Zhang   +7 more
wiley   +1 more source

Comprehensive Assessment of Herbicide Toxicity on Navicula sp. Algae: Effects on Growth, Chlorophyll Content, Antioxidant System, and Lipid Metabolism. [PDF]

Mar Drugs
Zheng C, Yang J, Wang Y, Ahmed W, Khan A, Li J, Weng J, Mehmood S, Li W.   +8 more
europepmc   +1 more source

The low-temperature solubility of aniline, the toluidines and some of their N-alkyl derivatives in aviation gasoline [PDF]

Kelly, Richard L
core   +1 more source

Mechanisms of hesperetin in alleviating diabetic nephropathy: Network pharmacology, molecular docking, and experimental validation

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 576-587, April 2026.
Hesperetin increases cell viability and reduces cell apoptosis, ferroptosis, release of inflammatory cytokines, and oxidative stress of human kidney tubular cells via repressing IGF1R expression. ABSTRACT Background Diabetic nephropathy (DN) accounts for approximately 50% of chronic kidney disease cases.
Yiwen Guo, Fengjiao Zhang, Yu Jin, Menglu Zhu, Zhiqiang Kang   +4 more
wiley   +1 more source