In Switzerland, most dispensed medications with teratogenic effect debated or proven were in the group of weak teratogenicity level. Reassuringly, many women discontinue treatment with potential teratogens before pregnancy. Abstract Introduction Exposure to potentially teratogenic medications during pregnancy is underinvestigated in Switzerland.
Carole A. Marxer+5 more
wiley +1 more source
Review of Tolvaptan in the Treatment of Hyponatremia [PDF]
Hyponatremia is a very common electrolyte disorder and is a significant independent predictor of medical prognosis and costs. Tolvaptan is a vasopressin receptor antagonist developed for the treatment of hyponatremia. It has its principal application in the treatment of euvolemic and hypervolemic hyponatremia.
Apurv Khanna, Amarinder Singh Garcha
openaire +2 more sources
Automated Microfluidic Platform for High‐Throughput Biosensor Development
Nanopore‐based biosensors are transformative for point‐of‐care diagnostics. This study introduces Bio‐Sensei, a high‐throughput microfluidic IoT platform integrating robotic sampling, electrochemical, and fluorescence setup. Functionalized with an ATCUN peptide for Cu2⁺ detection, it achieves LODs of 10⁻⁶ and 10⁻¹⁵ M in fluorescence and I–V ...
Shitanshu Devrani+2 more
wiley +1 more source
Terapia diuretica nell’insufficienza cardiaca cronica: evidenze, esperienze, prospettive = Diuretic treatment in patients with chronic heart failure: evidences, experiences, and current perspectives [PDF]
Congestion is a fundamental clinical sign in patients with chronic heart failure (CHF). Diuretics are the mainstay treatment for congestion but, so far, no randomized trial has ever shown any beneficial effect of diuretics on mortality in patients with ...
Carubelli, Valentina+1 more
core +1 more source
Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches
PROTEOMICS, EarlyView.
Paul Perco+7 more
wiley +1 more source
Prognostic impact of being underweight in patients undergoing mitral TEER: The OCEAN‐Mitral registry
Of the patients undergoing mitral transcatheter edge‐to‐edge repair, 20.9% were underweight, with a body mass index less than 18.5 kg/m2. Underweight patients had higher rates of all‐cause, cardiovascular, and non‐cardiovascular mortality, and being underweight was independently associated with all‐cause and cardiovascular mortality.
Ryosuke Higuchi+25 more
wiley +1 more source
Predictors of the Effect of Tolvaptan on the Prognosis of Cirrhosis
Objective Tolvaptan was first approved for use for cirrhosis in Japan in September 2013. The aim of the study was to examine the effect of tolvaptan, a vasopressin V2 receptor antagonist, on the prognosis of cirrhosis. Methods The effect of tolvaptan was evaluated in 26 patients with cirrhosis treated at our hospital from September 2013 to April 2015 ...
Taro Takami+9 more
openaire +4 more sources
Abstract Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been widely demonstrated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization, regardless of left ventricular ejection fraction (LVEF). However, data on the extent to which rehospitalization is suppressed following HF hospitalization are limited.
Michitaka Amioka+6 more
wiley +1 more source
International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people [PDF]
These recommendations were systematically developed on behalf of the Network for Early Onset Cystic Kidney Disease (NEOCYST) by an international group of experts in autosomal dominant polycystic kidney disease (ADPKD) from paediatric and adult nephrology,
Bergmann, Carsten+23 more
core +2 more sources