Results 41 to 50 of about 425,854 (315)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Quantifying lung growth with CT-derived intrapulmonary vascular volume: a cross-sectional study

BMC Medical Imaging
Background This study aimed to evaluate lung growth by the quantitative assessment of intrapulmonary vascular volume on chest CT images. Methods All 1122 subjects were grouped with a 2-year age span.
Meijuan Shi, Peng Gao, Meng Li, Weili Yang, Nan Yin, Youmin Guo, Cong Shen   +6 more
doaj   +1 more source

LEVELS OF PATIENTS EXPOSURE AND A POTENTIAL FOR OPTIMIZATION OF THE PET DIAGNOSTICS IN THE RUSSIAN FEDERATION

Радиационная гигиена, 2018
This study presents an overview of the most common positron emission tomography examinations in Russia, as well as the acquisition protocols and patient doses.
L. A. Chipiga, I. A. Zvonova, D. V. Ryzhkova, M. A. Menkov, М. B. Dolgushin   +4 more
doaj   +1 more source

Splenosis Mimicking Peritoneal Seeding of Advanced Colon Cancer Can Be Identified by Spleen SPECT/CT and FDG PET/CT

Diagnostics, 2021
This case report demonstrates that Tc-99m labeled heat-damaged red blood cell single-photon emission computed tomography/computed tomography (spleen SPECT/CT) and F-18 fluorodeoxyglucose positron emission tomography/CT (FDG PET/CT) could noninvasively ...
Ji Young Lee, Hee-Sung Song, Jimin Han
doaj   +1 more source

Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modelling

, 2002
A kinetic modelling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET) is presented. The approach is based on a general compartmental description of the tracer’s fate in vivo and determines a ...
Roger N. Gunn, Gunn, S R, Turkheimer, F E ; id_orcid, Aston, J A D, John A. D. Aston, Cunningham, T J, Turkheimer, F.E., Aston, J.A.D., Gunn, S.R., Gunn, R.N., Federico E. Turkheimer, Steve R. Gunn, Vincent J. Cunningham, Cunningham, V.J., Gunn, R N   +14 more
core   +1 more source

Computed tomography-osteoabsorptiometry for assessing the density distribution of subchondral bone as a measure of long-term mechanical adaptation in individual joints [PDF]

, 1989
To estimate subchondral mineralisation patterns which represent the long-term loading history of individual joints, a method has been developed employing computed tomography (CT) which permits repeated examination of living joints.
Müller-Gerbl, Magdalena, Wimmer, Berthold, Hodapp, Norbert, Putz, Reinhard, Schulte, Erik   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Role of ¹¹C-Methionine PET/CT in ^99mTc-Sestamibi-Negative Parathyroid Adenoma: A Case Report

Diagnostics, 2021
We report a case of 16-year-old female primary hyperparathyroidism patient who underwent cervical ultrasonography and 99mTc-sestamibi single photon emission computed tomography/computed tomography, both of which were negative for parathyroid adenoma ...
Jang Yoo, Miju Cheon
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

First-line treatments for extensive-stage small-cell lung cancer with immune checkpoint inhibitors plus chemotherapy: a China-based cost-effectiveness analysis

Frontiers in Immunology
ObjectiveTo determine the cost-effectiveness of imported immune checkpoint inhibitors (ICIs) such as atezolizumab and durvalumab, and domestic ICIs like serplulimab and adebrelimab, in combination with chemotherapy for extensive-stage small cell lung ...
Lidan Yi, Zhen Zhou, Xiaohui Zeng, Chongqing Tan, Qiao Liu   +4 more
doaj   +1 more source