Results 41 to 50 of about 8,105,618 (257)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Two-view topogram-based anatomy-guided CT reconstruction for prospective risk minimization

Scientific Reports
To facilitate a prospective estimation of the effective dose of an CT scan prior to the actual scanning in order to use sophisticated patient risk minimizing methods, a prospective spatial dose estimation and the known anatomical structures are required.
Chang Liu, Laura Klein, Yixing Huang, Edith Baader, Michael Lell, Marc Kachelrieß, Andreas Maier   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Relationships between lamb carcass quality traits measured by X-ray computed tomography (CT) and current UK-hill sheep breeding goals. [PDF]

, 2008
Genetic parameters were estimated between current UK hill sheep breeding goals and lamb carcass composition and muscularity traits derived using X-ray computed tomography (CT).
McLean, KA, McLaren, A., Lambe, NR; id_orcid, Bishop, S. C., Simm, Geoff, Lambe, N. R., Bünger, L., McLean, K. A., Conington, JE; id_orcid, McLaren, A; id_orcid, Bishop, SC, Simm, G, Bunger, L, Conington, J.   +13 more
core  

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

The Effect of Fiber Architecture on the Conductance of Inkjet Printed Ag on Electronic Textile Substrates

Small Structures
A nanoparticle Ag ink has been inkjet printed on six different plain‐weave polyester textile substrates without any further surface treatment. They are manufactured from the same composition of polyester fibers but with different fiber diameters and yarn
Zixin Wang, Tristan Lowe, Brian Derby
doaj   +1 more source

Modern principles of the radiation protection from sources of ionizing radiation in medicine. Part 1: Trends, structure of x-ray diagnostics and doses from medical exposure

Радиационная гигиена, 2019
Implementation of modern highly informative methods of X-ray diagnostics (computed tomography, interventional examinations, nuclear medicine), associated with the increase of doses to the public and patients, requires the development and improvement of ...
G. G. Onischenko, A. Yu. Popova, I. K. Romanovich, A. V. Vodovatov, N. S. Bashketova, O. A. Istorik, L. A. Chipiga, I. G. Shatsky, L. V. Repin, A. M. Biblin   +9 more
doaj   +1 more source

Multi-Detector CT Findings of Typical and Atypical Appendicitis: A Pictorial Essay

Journal of the Korean Society of Radiology, 2023
Multi-detector CT (MDCT) is a highly accurate diagnostic tool that is commonly used to evaluate appendicitis and its complications. The diagnosis of appendicitis based on MDCT findings can be difficult and challenging when the observed findings are ...
Na Ri Yun, You Dong Won, Su Lim Lee
doaj   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source