Results 151 to 160 of about 5,881 (273)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

From pupil to performance : exploring the role of tonic norepinephrine levels in response inhibition using pretrial pupil measures

Response inhibition is key to flexible behavior. Importantly, performance in any task, including response inhibition tasks, fluctuates on a moment‐to‐moment basis. Using pupillometry, we investigated the relationship between these behavioral fluctuations
Cabooter, Quinn, Wardhani, Intan Kusuma, Doekemeijer, Roos, Verbruggen, Frederick, Böhler, Nico   +4 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Adie's tonic pupil after COVID-19: a case report and literature review. [PDF]

Rom J Ophthalmol
Çakır GY, Paşaoğlu IB, Çakır İ, Solmaz B.   +3 more
europepmc   +1 more source

Tonic pupil after botulinum toxin-A injection for treatment of esotropia in children. [PDF]

J AAPOS, 2016
Pediatric Eye Disease Investigator Group, Christiansen SP, Chandler DL, Lee KA, Superstein R, de Alba Campomanes A, Bothun ED, Morin J, Wallace DK, Kraker RT.   +9 more
europepmc   +1 more source

[PREPRINT] From Pupil to Performance: Exploring the role of tonic norepinephrine levels on response inhibition using pretrial pupil measures

Response inhibition is key to flexible behavior. Importantly, performance in any task, including response inhibition tasks, fluctuates on a moment-to-moment basis. Using pupillometry, we investigated the relationship between these behavioral fluctuations
Frederick Verbruggen, Roos Arwen Doekemeijer, C. Nico Boehler, Quinn Cabooter, Intan K. Wardhani   +4 more
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Cholinergic‐related pupil activity reflects level of emotionality during motor performance

Pupil size covaries with the diffusion rate of the cholinergic and noradrenergic neurons throughout the brain, which are essential to arousal. Recent findings suggest that slow pupil fluctuations during locomotion are an index of sustained activity in ...
Onderdijk, Kelsey E.0001715376288020028181879760918280490000-0001-9992-762026BDC8DA-086D-11E8-A1A2-03F311A95AF2, Six, JorenLW030001307802488020016256930000-0001-7671-1907B7F7267C-1676-11E3-8020-67D810BDE39D, Fritz, ThomasLW1780200091355331448AC4-F0EE-11E1-A9DE-61C894A0A6B4, Aguilera, Ana M., Maes, Pieter-JanLW170020042768468020004764470000-0002-9237-3298FBC3F8B2-F0ED-11E1-A9DE-61C894A0A6B4, Vidal, MarcPP010001813276558020030368430000-0002-1084-324272FE6EC6-D3EB-11E8-83F6-28815607D3EF, Leman, MarcLW178010006005480000-0002-9780-2194F42EEEB8-F0ED-11E1-A9DE-61C894A0A6B4   +6 more
core