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Formation and disruption of tonotopy in a large-scale model of the auditory cortex
Journal of Computational Neuroscience, 2015There is ample experimental evidence describing changes of tonotopic organisation in the auditory cortex due to environmental factors. In order to uncover the underlying mechanisms, we designed a large-scale computational model of the auditory cortex.
Markéta, Tomková +5 more
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Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptor
Hearing Research, 2005Sensory cortices have multiple and distinct functional maps that systematically represent environmental information. Development of these maps is precisely controlled by a number of intrinsic and extrinsic factors. Cortical cholinergic regulation is a crucial factor for normal cortical morphogenesis. In this study, we test the role of the M1 muscarinic
Yunfeng, Zhang +4 more
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Rapid Integration Across Tonotopy by Individual Auditory Brainstem Octopus Cells
2013Broadband transient sounds, such as clicks, are transduced in a traveling wave in the cochlea that spreads from base to apex. This traveling wave causes delays in the activation of auditory nerve fibers that vary systematically as a function of the tonotopy in the ventral cochlear nucleus (VCN) in the brainstem, activating high-frequency fibers first ...
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Tunability strategies for elastic metamaterials: waveguiding, tonotopy and topological localization
In this talk, I will present recent work by our group documenting two different approaches to achieve dynamic tunability in elastic metamaterials, and some of the possible applications deriving from their augmented functionality. On the one hand, photoresponsive polymers can be used to reversibly locally modify material stiffness through the ...openaire +1 more source
Patients with similar audiograms often experience varying levels of difficulty in understanding speech in noisy environments, despite using state-of-the-art hearing aids. With audibility largely restored by amplification, these divergent suprathreshold outcomes are often attributed to reduced frequency selectivity (i.e., broadening of the so-called ...
Bharadwaj, Hari +4 more
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Bharadwaj, Hari +4 more
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