Results 11 to 20 of about 1,471 (132)
Cochlear tonotopy from proteins to perception
BioEssays, 2023 AbstractA ubiquitous feature of the auditory organ in amniotes is the longitudinal mapping of neuronal characteristic frequencies (CFs), which increase exponentially with distance along the organ. The exponential tonotopic map reflects variation in hair cell properties according to cochlear location and is thought to stem from concentration gradients ...
Robert Fettiplace
wiley +4 more sources
Linking Topography to Tonotopy in the Mouse Auditory Thalamocortical Circuit [PDF]
The Journal of Neuroscience, 2011 The mouse sensory neocortex is reported to lack several hallmark features of topographic organization such as ocular dominance and orientation columns in primary visual cortex or fine-scale tonotopy in primary auditory cortex (AI). Here, we re-examined the question of auditory functional topography by aligning ultra-dense receptive field maps from the ...
Troy A. Hackett +4 more
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Strengthening of the efferent olivocochlear system leads to synaptic dysfunction and tonotopy disruption of a central auditory nucleus [PDF]
The Journal of Neuroscience, 2018 AbstractThe auditory system in many mammals is immature at birth but precisely organized in adults. Spontaneous activity in the inner ear plays a critical role in guiding this process. This is shaped by an efferent pathway that descends from the brainstem and makes transient direct synaptic contacts with inner hair cells (IHCs).
Mariano N. Di Guilmi +6 more
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Tonotopy is not preserved in a descending stage of auditory cortex
Abstract Previous studies based on layer specificity suggest that ascending signals from the thalamus to sensory neocortex preserve spatially organized information, but it remains unknown whether sensory information descending from sensory neocortex to thalamus also maintains such spatial organization pattern.
Miaoqing Gu +13 more
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Structural and functional effects of acoustic exposure in goldfish: evidence for tonotopy in the teleost saccule [PDF]
BMC Neuroscience, 2011 Mammalian and avian auditory hair cells display tonotopic mapping of frequency along the length of the cochlea and basilar papilla. It is not known whether the auditory hair cells of fishes possess a similar tonotopic organization in the saccule, which is thought to be the primary auditory receptor in teleosts.
Michael E. Smith +3 more
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eLife, 2019 Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which transmembrane channel-like 1 (TMC1) and transmembrane channel-like 2 (TMC2) have been proposed to be the pore-forming subunits in mammals.
Shuang Liu +9 more
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development of tonotopy in the inferior colliculus. I. Electrophysiological mapping in house mice [PDF]
Developmental Brain Research, 1990 The development of the size and tonotopy of the mouse inferior colliculus (IC) was studied at postnatal ages of 9-20 days. During that time, the size of the IC remained constant in all 3 planes (rostrocaudal, mediolateral dorsoventral). At day 10, the first low-frequency responses without tonotopy could be recorded from neurons in the rostral and ...
R. Romand, Günter Ehret
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Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells
Hearing Research, 2018 Ototoxicity, noise overstimulation, or aging, can all produce hearing loss with similar properties, in which outer hair cells (OHCs), principally those at the high-frequency base of the cochlea, are preferentially affected. We suggest that the differential vulnerability may partly arise from differences in Ca2+ balance among cochlear locations ...
Robert Fettiplace, Jong-Hoon Nam
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Fractured tonotopy of functional neural clusters in mouse auditory cortex [PDF]
, 2016 AbstractThe degree of order versus randomness in mammalian cortical circuits has been the subject of much discussion. Previous reports showed that at a large scale there is smooth tonotopy in mouse auditory cortex, while at the single neuron level the representation is the traditional “salt and pepper” configuration attributed to rodent cortex. Here we
Isabel Delgado Ruz, Simon R. Schultz
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Dissociation of tonotopy and pitch in human auditory cortex [PDF]
, 2020 SUMMARYFrequency-to-place mapping, or tonotopy, is a fundamental organizing principle from the earliest stages of auditory processing in the cochlea to subcortical and cortical regions. Although cortical maps are referred to as tonotopic, previous studies employed sounds that covary in spectral content and higher-level perceptual features such as pitch,
Emily Allen +3 more
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