Results 31 to 40 of about 7,808 (141)

Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng, Tereza Vitkovska, Song Hon Hwang, Lauran K. Evans, Hong‐Ho Yang, Christopher Dann, Dipti Sajed, Maie A. St. John   +7 more
wiley   +1 more source

Transoral Robotic Resection of Glossopharyngeal Neurofibroma: A Case Report

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT This case highlights the diagnostic challenges posed by rare oropharyngeal neurofibromas, their potential to mimic other conditions, and the novel application of transoral robotic surgery (TORS) for the management of an oropharyngeal neurofibroma. A 47‐year‐old female presented with a 1‐year history of a left tonsillar mass.
Cody L. Messick, Austin R. Swisher, Hannah M. Gibbs, Michael T. Sramek, Laura Klusovsky, Payam Entezami, James S. Lewis Jr., Brent A. Chang   +7 more
wiley   +1 more source

Tongue gangrene and oropharyngeal carcinoma

Clinical and Biomedical Research, 2016
Gangrene of the tongue is a condition rarely described in the literature. It generally occurs in association with temporal arteritis and other vasculitides. We described a rare case of tongue necrosis associated with oropharyngeal carcinoma.
Fabio Muradás Girardi, Eduardo Lange Rech, Victória Teles França, Luiz Inácio Roman   +3 more
doaj   +2 more sources

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

CD49a expression defines a metabolically robust, cytokine‐biased liver NK cell subset in rhesus macaques during lentivirus infection

Immunology &Cell Biology, EarlyView.
Liver‐resident NK cells (CD49a+ NK cells) in rhesus macaques display distinct activating receptor and metabolic markers enhanced phenotype compared with hepatic NK cell subsets (CD49a−) in the liver. These cells exhibit heightened cytokine polyfunctionality with restrained cytotoxic responses upon mitogen stimulation in comparison with CD49a− NK cell ...
Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam   +4 more
wiley   +1 more source

Assessing mature and immature collagen in tonsillar tissue using second harmonic generation microscopy

Journal of Microscopy, EarlyView.
Abstract Recurrent tonsillitis (RT) and obstructive sleep apnoea (OSA) are major indications for tonsillectomy, yet their tissue‐level pathology remains unclear. Recurrent inflammation in RT may induce collagen remodelling through excess extracellular matrix deposition.
Kay Polland, Megan Clapperton, Thushitha Kunanandam, Catalina D Florea, Catriona M Douglas, Gail McConnell   +5 more
wiley   +1 more source

Case report on activated PI3K-delta syndrome

Boletín Médico del Hospital Infantil de México
Background: Activated phosphoinositide 3-kinase delta syndrome (APDS) [OMIM 615513] is an inborn error of immunity with autosomal dominant inheritance caused by a pathogenic variant in the PIK3CD gene.
Israel E. Crisanto-López, Alan A. Pérez-Arzola, Yazmin Hernández-Castañeda, Reyna G. Carrasco-Trinidad, Aurea Vera-Loaiza, Berenice Jiménez-Pérez, Tania A. Guzmán-Santiago, Pablo O. Rodríguez-Hurtado, Wilbert Salazar-Bonilla, Daniela Juárez-Melchor   +9 more
doaj   +1 more source

Computed tomographic features of presumed normal palatine tonsils in 140 dogs

Journal of Small Animal Practice, EarlyView.
Objectives The purpose of this retrospective study was to describe the CT features of presumed normal canine palatine tonsils. Materials and Methods Pre‐ and post‐contrast head CT studies of 140 dogs without tonsillar disease were included. Subjective evaluation of palatine tonsils included contrast enhancement pattern, differentiation from surrounding
N. Leong, R. Drees, H. Dirrig
wiley   +1 more source

Case Report: Unclassifiable cerebellar high-grade neuroepithelial tumor with a CCDC6::RET fusion manifesting explosive recurrence

Frontiers in Surgery
A 20-year-old woman presented with a 1-month history of positional vertigo, occipital headaches, and progressive gait ataxia. Neuroimaging demonstrated a 3.7 × 4.2 × 3.3 cm heterogeneously enhancing mass in the left cerebellar hemisphere with fourth ...
Moksada Regmi, Moksada Regmi, Moksada Regmi, Moksada Regmi, Shikun Liu, Shikun Liu, Shikun Liu, Ying Xiong, Ying Xiong, Ying Xiong, Junyi Liu, Junyi Liu, Junyi Liu, Zihan Zhao, Xu Zhang, Xu Zhang, Chenlong Yang, Chenlong Yang, Chenlong Yang, Sino-Uzbek Regenerative Therapy Consortium (SURE)   +19 more
doaj   +1 more source

Endoscopic‐Assisted Posterior Atlantoaxial Fusion: Technical Innovation and Clinical Experience

Orthopaedic Surgery, EarlyView.
Endoscopic‐assisted posterior atlantoaxial lateral mass fusion is introduced as a novel minimally invasive technique for treating atlantoaxial instability. The approach enables direct visualization, precise fixation, and effective bone fusion while minimizing muscle dissection, blood loss, and postoperative pain, achieving rapid neurological and ...
Jichong Zhu, Chengqian Huang, Jiang Xue, Jiarui Chen, Yufan Xu, Dequan Liu, Xinli Zhan, Chong Liu   +7 more
wiley   +1 more source