Results 61 to 70 of about 92,153 (184)

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Cystic Lesions of the Pancreas [PDF]

, 2014
With the increasing use of abdominal imaging, cystic lesions of the pancreas are being more frequently detected. These lesions may carry a significant premalignant potential.
Azzopardi, Neville
core  

Assessing mature and immature collagen in tonsillar tissue using second harmonic generation microscopy

Journal of Microscopy, EarlyView.
Abstract Recurrent tonsillitis (RT) and obstructive sleep apnoea (OSA) are major indications for tonsillectomy, yet their tissue‐level pathology remains unclear. Recurrent inflammation in RT may induce collagen remodelling through excess extracellular matrix deposition.
Kay Polland, Megan Clapperton, Thushitha Kunanandam, Catalina D Florea, Catriona M Douglas, Gail McConnell   +5 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Neuroendocrine Neoplasms

, 2022
Pancreatic neuroendocrine neoplasms (PanNENs) are tumors with neuroendocrine differentiation and are divided into functioning (syndromic) or non-functioning based on the clinical syndromes. Insulinomas are the most common functioning NETs.
Maria Gaia Mastrosimini, Lavinia Stefanizzi, Stefano Gobbo, Paola Capelli, Paolo Tinazzi Martini, Aldo Scarpa, Mirko D’Onofrio, Riccardo De Robertis, Alessandro Beleù, Luca Geraci   +9 more
core   +1 more source

Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report

Frontiers in Immunology
Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) and nodal T follicular helper cell lymphoma, angioimmunoblastic type (TFHL-AI) share significant histopathological and pathogenetic similarities. However, the mechanisms underlying these
Qing Li, Shishuo Dai, Chenlu Yang, Weiping Liu, Yu Wu   +4 more
doaj   +1 more source

Impact of Co‐Morbid Immunocompromise in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

The Laryngoscope, Volume 136, Issue 10, Page 4279-4289, October 2026.
Among patients with surgically resected Human Papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC), immunocompromised patients had significantly worse overall survival compared to the non‐compromised group; however, these exploratory findings should be interpreted cautiously.
Maxwell L. Weng, Tereza Vitkovska, Song Hon Hwang, Lauran K. Evans, Hong‐Ho Yang, Christopher Dann, Dipti Sajed, Maie A. St. John   +7 more
wiley   +1 more source

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, Volume 159, Issue 6, Page 1535-1545, 15 September 2026.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source

Targeted Tonsillar Biopsy for Unilateral Tonsillar Enlargement

, 2017
Background: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement. Methods: This is a retrospective case series of all cases
Truong An Pham, Robert G Berkowitz
core   +1 more source

Incidence of synchronous contralateral tonsillar malignancy in a known case of unilateral tonsillar carcinoma

, 2022
Objective: The literature is divided with regards to contralateral tonsillectomy in a known/suspected case of ipsilateral tonsillar malignancy. In this study, we evaluate the incidence of indolent synchronous contralateral tonsillar malignancy (SCTC) in ...
Ahmad, Shoaib, Hussain, Mohammed H., Vaidhyanath, Ram, Fagiry, Rihab, Ahmed, Tauseef, Conboy, Peter, Oladejo, Olaleye, Baker, Andrew, Mahmood, Sara, Mair, Manish, Eltayeb, Mandy   +10 more
core   +1 more source