Results 131 to 140 of about 5,252,997 (308)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Integrated Machine Tool Design

, 2009
Today's global market is fiercely competitive. This circumstance, combined with increasing pace of technological development and customers demanding high-quality custom or semi-custom solutions, produces a highly dynamic engineering context. For example, aeronautical sector requires high-performance machining of innovative hard materials, both metallic
Cau N, Leonesio M, Zanotti E, Parenti P, Bianchi G   +4 more
openaire   +3 more sources

Visualising ergonomics data for design [PDF]

, 2011
Existing ergonomics data are not effectively used by designers; this is mainly because the data are not presented in a designer-friendly format. In order to help designers make better use of ergonomics data, we explored the potential of representing ...
Chen, H, Dong, H, Macredie, R, Pei, E
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Process Parameters and Tool Design in Friction Stir Extrusion: A Sustainable Recycling Technique

Engineering Reports
Friction stir extrusion (FSE) is a versatile technique that plays a dual role in sustainable recycling and shaping of materials. This method involves a rotating mandrel and a fixed matrix within a mold, where compressed waste metal chips or primary bulk ...
Mostafa Akbari, Parviz Asadi, Reza Abdi Behnagh, Fevzi Bedir, Naghdali Choupani, Tomasz Sadowski   +5 more
doaj   +1 more source

Application of Mineral Casting for Machine Tools Beds. [PDF]

, 2013
The article provides state of the art and the latest development trends in the manufacturing of machine tool beds. The emphasis is placed on modern materials whose mechanical and dynamical properties may prove to be a breakthrough in the field of machine
Kępczak, Norbert, Pawłowski, Witold
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimization of Material Utilization by Developing a Reliable Design Criterion for Tool Construction in Cross-Wedge Rolling

Journal of Manufacturing and Materials Processing
The massive forming industry in Germany produces around 1.4 million parts every year, which are mainly used in safety-relevant areas such as the automotive industry.
Patrick Kramer, Abdulkerim Karaman, Michael Marré   +2 more
doaj   +1 more source

PerspectivesX: A Proposed Tool to Scaffold Collaborative Learning Activities within MOOCs

, 2017
In this work-in-progress paper, we introduce the PerspectivesX tool which aims to scaffold collaborative learning activities within MOOCs. The PerspectivesX tool has been designed to promote learner knowledge construction and curation for a range of ...
Bakharia, Aneesha
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source