Results 71 to 80 of about 5,252,997 (308)
Post-Series Design: a tool for catalysing the diffusion of personalisable design. [PDF]
, 2018 Today a range of increasingly mainstream Digital Fabrication tools help designers not only in prototyping, but also in the production of final parts for consumer products. These hardware tools, while still have significant limitations, they already offer
ALAMO AVILA, Ainee +3 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Materials & DesignMedium manganese steels (MMnS) exhibit exceptional strength-ductility synergy due to the well-known transformation induced plasticity (TRIP) effects, making it a prime candidate for automotive lightweighting and safety–critical structures.
Ning Guo +3 more
doaj +1 more source
Assessing the Complexity of a Recovered Design and its Potential Redesign Alternatives [PDF]
, 2009 Organised by: Cranfield UniversityReverse engineering techniques are applied to generate a part model where there is no existing documentation or it is no longer up to date.
ElMaraghy, W. H., Urbanic, R. J.
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Journal of Materials Research and TechnologyThis study innovatively employs the “ultrasonic vibration + self-riveting” (UR) hybrid technique for friction stir lap welding (FSLW) of 2.5 mm thick 6061-T6 aluminum alloy to 1.8 mm thick Q235 steel, systematically investigating its effects on joint ...
Qipeng Yin +6 more
doaj +1 more source
Novel Tool Design Method for Orbiting EDM
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010 Tool design for orbiting EDM process often encounters some difficulties to adjust for EDM orbit and machining overcut concurrently. In orbiting process, the tool sweeps out some extra volume due to the additional orbit motion.
Tutik SRIANI, Hideki AOYAMA
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source