Results 81 to 90 of about 5,252,997 (308)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Powerful Optimization Tool for Analog Integrated Circuits Design [PDF]

, 2013
This paper presents a new optimization tool for analog circuit design. Proposed tool is based on the robust version of the differential evolution optimization method. Corners of technology, temperature, voltage and current supplies are taken into account
Jakovenko, J., Kubar, M.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Relationship Between Carbon Emissions and Ecosystem Services in Guangdong Province, China: The Perspective of Ecological Function Zones

Land
Ecosystem carbon sinks can offset part of the carbon emissions from human activities, playing a significant role in the carbon neutrality process. Clarifying the relationship between carbon emissions and ecosystem services is crucial for achieving the ...
Yanqing Lang, Heng Chao, Jingyu Xiao
doaj   +1 more source

Monitoring Conceptual Development: Design Considerations of a Formative Feedback tool [PDF]

, 2010
This paper presents the design considerations of a tool aiming at providing formative feedback. The tool uses Latent Semantic Analysis, to automatically generate reference models and provide learners a means to compare their conceptual development ...
Berlanga, Adriana J., Braidman, Isobel, Smithies, Alisdair, Wild, Fridolin   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Toward a user-oriented analytical approach to learning design [PDF]

, 2008
The London Pedagogy Planner (LPP) is a prototype for a collaborative online planning and design tool that supports lecturers in developing, analysing and sharing learning designs.
Boyle, Tom, Bradley, Claire, Laurillard, Diana, Ljubojevic, Dejan, Neumann, Tim, Pearce, Darren, San Diego, Jonathan   +6 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Designing a tool to analyse the performance of biological systems

Activités, 2007
New cultivars have always been a key element in the development of cropping systems. The assessment of new cultivar performance in a diverse range of environments (soil, climate, production methods) is a key issue for the actors along the chain which ...
Lorène Prost, Christophe Lecomte, Jean-Marc Meynard, Marianne Cerf   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source