Results 51 to 60 of about 9,278,986 (351)

Pragmatic screening for heart failure in the general population using an electrocardiogram‐based neural network

ESC Heart Failure, 2023
Aims We aim to develop a pragmatic screening tool for heart failure at the general population level. Methods and results This study was conducted within the Hamburg‐City‐Health‐Study, an ongoing, prospective, observational study enrolling randomly ...
Kishore Surendra, Sylvia Nürnberg, Jan P. Bremer, Marius S. Knorr, Frank Ückert, Jan Per Wenzel, Ramona Bei der Kellen, Dirk Westermann, Renate B. Schnabel, Raphael Twerenbold, Christina Magnussen, Paulus Kirchhof, Stefan Blankenberg, Johannes Neumann, Benedikt Schrage   +14 more
doaj   +1 more source

Retraction: Nahar et al. PSHRisk-Tool: A Python-Based Computational Tool for Developing Site Seismic Hazard Analysis and Failure Risk Assessment of Infrastructure. Appl. Sci. 2020, 10, 7487

Applied Sciences, 2022
The journal retracts the article, “PSHRisk-Tool: A Python-Based Computational Tool for Developing Site Seismic Hazard Analysis and Failure Risk Assessment of Infrastructure” [...]
Tahmina Tasnim Nahar, Md Motiur Rahman, Dookie Kim   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An Investigation of the Adhesive Effect on the Flank Wear Properties of a WC/Co-based TiAlN-Coated Tool for Milling a Be/Cu Alloy

Metals, 2019
In this paper, an experimental investigation, based on force special parameters, is adopted to analyze the relationship between the milling tool and adhesive phenomena in milling C17200.
Junyan Zuo, Youxi Lin, Ming He
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Systematic examination of a heart failure risk prediction tool: The pooled cohort equations to prevent heart failure.

PLoS ONE, 2020
Identification of individuals at risk for heart failure is needed to deliver targeted preventive strategies and maximize net benefit of interventions. To examine the clinical utility of the recently published heart failure-specific risk prediction model,
Aakash Bavishi, Donald M Lloyd-Jones, Hongyan Ning, Thanh Huyen T Vu, Clyde W Yancy, Sanjiv J Shah, Mercedes Carnethon, Sadiya S Khan   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A qualitative study of a primary-care based intervention to improve the management of patients with heart failure : the dynamic relationship between facilitation and context [PDF]

, 2014
Background: There is currently a growing emphasis in primary care on upscaling the provision of evidence-based services for specific conditions, such as heart failure (HF), which have traditionally been seen as part of a specialist’s domain.
Stephanie Tierney, Kislov, R, Tierney, Stephanie, Roman Kislov, Kislov, Roman, Kislov, Roman; id_orcid, Deaton, Christi, Tierney, S, Deaton, C, Christi Deaton   +9 more
core   +1 more source

Benchmarking and Validation of Cascading Failure Analysis Tools

IEEE Transactions on Power Systems, 2016
Cascading failure in electric power systems is a complicated problem for which a variety of models, software tools, and analytical tools have been proposed but are difficult to verify. Benchmarking and validation are necessary to understand how closely a particular modeling method corresponds to reality, what engineering conclusions may be drawn from a
Bialek, J.W., Ciapessoni, E., Cirio, D., Cotilla-Sanchez, E., Dent, C.J., Dobson, I., Henneaux, P., Hines, P., Jardim, J., Miller, S., Panteli, M., Papic, M., Pitto, A., Quiros-Tortos, J., Wu, D.   +14 more
openaire   +7 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source