Results 31 to 40 of about 242,243 (268)
Block Overlap Based CNC Interpolator with Variable Time Constant [PDF]
한국정밀공학회지This paper proposed a CNC interpolator based on block overlap, capable of changing acceleration and deceleration time constants during continuous machining. The time constant can be set individually for each block through G-code commands.
Chan-Young Lee +3 more
doaj +1 more source
Automatic Tool Path Generation for Parametric Surfaces [PDF]
Engineering and Technology Journal, 2019 A tool path generation algorithm has been proposed and implemented in the presented work. The aim of the development of tool path algorithm is to machine parametric surface with a given tolerance and scallop height.
Tahseen Abbas, Sara Shawi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Tool path in torus tool CNC machining
上海师范大学学报. 自然科学版, 2016 This paper is about tool path in torus tool CNC machining.The mathematical model of torus tool is established.The tool path planning algorithm is determined through calculation of the cutter location,boundary discretization,calculation of adjacent tool ...
XU Ying, LI Ruqiong
doaj +1 more source
Reconfigurable Computing for Tool-Path Computation
The International Journal of Advanced Manufacturing Technology, 2003 Tool path generation is one of the most complex problems in Computer Aided Manufacturing. Although some efficient strategies have been developed to solve it, most of them are only useful for 3 and 5 axis standard machining. The algorithm called Virtual Digitising computes the tool path by means of a “virtually digitised” model of the surface and a ...
Jimeno-Morenilla, Antonio +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Canonical and Non-Canonical Approaches of the Discrete Teaching Learning Based Optimization [PDF]
International Journal of Mathematical, Engineering and Management SciencesManufacturing plays a crucial role in robust economies, and effective optimization of manufacturing processes ensures competitive viability. Multi-hole drilling is a fundamental process in manufacturing, especially in the mass production of boilerplates,
Vijay P. Rathod +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Automated selection of homologs to track the evolutionary history of proteins
BMC Bioinformatics, 2018 Background The selection of distant homologs of a query protein under study is a usual and useful application of protein sequence databases. Such sets of homologs are often applied to investigate the function of a protein and the degree to which ...
Pablo Mier +2 more
doaj +1 more source