Results 41 to 50 of about 73,589 (262)
Optimization of Boring Process Parameters in Manufacturing of Polyacetal Bushing using High Speed Steel [PDF]
E3S Web of Conferences, 2019 Polyacetal is commonly used as bushing material because of its low coefficient of friction and self lubricant characteristics. The polyacetal is machined by using boring process to produce bushing in certain surface roughness.
Jaya Suteja The +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The resistance of ledeburitic tool steels against the abrasive wear
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2012 The ledeburitic tool steels which used to be used mainly for cutting and shaping tools nowadays are frequently used for a manufacture of injection moulds, moulds for pressure castings of aluminium alloys and for moulds for ceramics processing.
Jaromír Liška, Josef Filípek
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Tribology Online, 2016 The plasma nitriding of tool steel under atmospheric-pressure was performed using a dielectric barrier discharge method, resulting in the formation of a uniform nitrided layer.
Junji Miyamoto +4 more
doaj +1 more source
AlTiN and AlTiON-coated hot work tool steels for tooling in steel thixoforming
Transactions of Nonferrous Metals Society of China, 2010 Abstract X32CrMoV33 hot work tool steel samples coated with AlTiN and AlTiON were submitted to thermal cycling under conditions that approximate thixoforming of steels and to sliding wear tests at 750 ?, measured to be the cavity surface temperature shortly after the steel slurry is forced into the thixoforming die.
Birol, Y., Isler, D.
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source