Results 111 to 120 of about 9,039,965 (305)
Topics in Cognitive ScienceAbstractMany core human activities require an understanding of time. To coordinate rituals, plan harvests and hunts, recall histories, keep appointments, and follow recipes, we need to grapple with invisible temporal structures like durations, sequences, and cycles. No other species seems to do this.
openaire +2 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
The NorduGrid architecture and tools
, 2003 The NorduGrid project designed a Grid architecture with the primary goal to meet the requirements of production tasks of the LHC experiments. While it is meant to be a rather generic Grid system, it puts emphasis on batch processing suitable for problems
Eerola, P. +9 more
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Chinese Journal of Mechanical EngineeringAvoiding crystallization while maintaining the original microstructure and mechanical properties of the material are long-term goals of laser welding of Zr-based bulk metallic glass (BMG).
Chengyong Wang +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A survey of the PEPA tools [PDF]
, 2003 This paper surveys the history and the current state of tool support for modelling with the PEPA stochastic process algebra and the PEPA nets modelling language. We discuss future directions for tool support for the PEPA family of languages.
Gilmore, Stephen, Hillston, Jane
core +1 more source
Advanced Material Studies for Additive Manufacturing in terms of Future Gear Application
Advances in Mechanical Engineering, 2014 Additive manufacturing by laser beam melting is predestined for complex component geometry like integrated cooling channels without enormous posttreatment processing.
Jan Bräunig +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source