Results 71 to 80 of about 864,598 (359)

Sirt6 loss activates Got1 and facilitates cleft palate through abnormal activating glycolysis

Cell Death and Disease
Cleft palate (CP) is a common congenital craniofacial malformation, which is caused by a combination of genetic and environmental factors. However, its underlying mechanism has not been elucidated.
Xiaotong Wang, Xige Zhao, Xiaoyu Zheng, Xia Peng, Jing Chen, Yijia Wang, Zhiwei Wang, Mingyue Meng, Juan Du   +8 more
doaj   +1 more source

DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling

Scientific Reports, 2021
Dentin phosphophoryn synthesized and processed predominantly by the odontoblasts, functions as both structural and signaling protein. Mechanistic studies revealed that DPP stimulation of DPSCs positively impacted the differentiation of DPSCs into ...
Yinghua Chen, Adrienn Pethö, Amudha Ganapathy, Anne George   +3 more
doaj   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction

International Journal of Oral Science
Alveolar bone resorption during the socket healing process compromises subsequent restoration outcomes. Recent clinical evidence suggests that dental implant placement can effectively prevent such bone loss, yet the mechanisms remain elusive.
Xue Jiang, Yuteng Weng, Yanhuizhi Feng, Jie Huang, Haicheng Wang, Zuolin Wang   +5 more
doaj   +1 more source

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls

Scientific Reports, 2018
Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored.
Yanan Qiao, Mingtao Wu, Yanhuizhi Feng, Zhichong Zhou, Lei Chen, Fengshan Chen   +5 more
doaj   +1 more source

Horizontal saddle-supported storage vessels: A parametric study of plastic collapse loads [PDF]

, 2003
Previous work by the present authors compared various theoretical methods with simple experiments for the plastic collapse load on end supported vessels loaded centrally by rigid saddles.
Chan, G.C.M., Nash, D.H., Spence, J., Tooth, A.S.   +3 more
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

In Situ Tantalum Doping of Titanium Dioxide Nanotubes via Electrochemical Method for Enhanced Mechanical and Biological Properties

Journal of Functional Biomaterials
Titanium dioxide nanotubes (TNTs) have favorable biocompatibility and nanoscale morphologies, and they have been extensively explored for titanium implant surface modifications.
Yao Yao, Yanting Mu, Wanting Li, Na Wang, Ran Lu, Su Chen   +5 more
doaj   +1 more source

Erupted Complex Odontoma Mimicking a Mandibular Second Molar [PDF]

, 2015
Complex odontoma (CO) is considered one of the most common odontogenic lesions, composed by a miscellaneous of dental tissue such as enamel, dentin, pulp and sometimes cementum.
Almeida, Luis Eduardo, Andrade, M. O., de Oliveira Filho, M. A., Doetzer, Andrea, Trevilatto, Paula C.   +4 more
core   +1 more source

An evaluation of mesiodentes: A retrospective study with cone-beam computed tomography [PDF]

, 2018
Background: The mesiodens, located in the palatal midline between the two maxillary central incisors, is the most common type of supernumerary tooth. The aim of this study was to evaluate the distribution of mesiodentes according to shape, position, and ...
Akay, Gülsün, Güngör, Kahraman, Özdede, Meli̇h   +2 more
core   +2 more sources