Results 181 to 190 of about 588,817 (292)

Randomized Controlled Clinical Trial Comparing Screw‐Retained Monolithic Zirconia Implant Crowns on Standardized Titanium Base Versus Customized Titanium Abutments– 3‐Years Data

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To assess 3‐year interim results of implant‐supported monolithic zirconia single crowns on standardized titanium base vs. customized titanium abutments. Material and Methods Patients in need of posterior implant were recruited.
Jenni Hjerppe   +5 more
wiley   +1 more source

Tin Sensitization in Belgium and the Netherlands: Complementary Findings From Two Independent Retrospective Studies

open access: yesContact Dermatitis, EarlyView.
In retrospective studies the prevalence of tin sensitization and its clinical relevance was evaluated in two groups: consecutive patients and patients suspected of metal allergies. The prevalence was higher than previously reported and relevance could be established for ~30%.
Sylvie M. Franken   +5 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

open access: yesCell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo   +10 more
wiley   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

open access: yesCell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu   +15 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

open access: yesCell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng   +8 more
wiley   +1 more source

Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU‐Mediated Mitochondrial Calcium Overload

open access: yesCell Proliferation, EarlyView.
Magnesium restores macrophage clearance of P. gingivalis by inhibiting MCU‐mediated calcium overload. P. gingivalis is mainly phagocytosed by macrophages but escapes intracellular clearance via MCU‐mediated mitochondrial and cytosolic Ca2+ overload in periodontitis. The persistent P.
Dao‐Kun Deng   +11 more
wiley   +1 more source

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

open access: yesCell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu   +7 more
wiley   +1 more source

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