Results 161 to 170 of about 10,658 (251)

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

open access: yesCell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng   +11 more
wiley   +1 more source

Tunnelling Nanotube‐Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy

open access: yesCell Proliferation, EarlyView.
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang   +16 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

open access: yesCell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo   +10 more
wiley   +1 more source

Prevalence of Post‐Operative Complications in Autotransplanted Teeth: A Long‐Term Retrospective Cohort

open access: yesDental Traumatology, EarlyView.
ABSTRACT Background/Aims To evaluate the prevalence and timing of post‐operative complications following tooth autotransplantation, identify factors associated with earlier diagnosis, and report long‐term survival and success rates. Materials and Methods A single‐centre retrospective cohort study was conducted at a Czech university dental clinic (2003 ...
Juraj Marton   +5 more
wiley   +1 more source

SOS Dental Trauma—An Artificial Intelligence Chatbot via WhatsApp for Guiding Patients After Dental Trauma

open access: yesDental Traumatology, EarlyView.
ABSTRACT Background Traumatic dental injuries (TDIs) are highly prevalent worldwide and require immediate and appropriate management to ensure favorable outcomes. The aim of the study was to develop and validate SOS Dental Trauma, an interactive artificial intelligence‐based chatbot integrated with WhatsApp.
Luana Beatriz das Portas Luiz   +9 more
wiley   +1 more source

Maltreatment and Dental Trauma in Preschool Children: A Cohort Study

open access: yesDental Traumatology, EarlyView.
ABSTRACT Background Child maltreatment (CM) has been associated with adverse oral health outcomes during childhood. However, few studies have investigated the relationship between CM and dental trauma (DT) in the primary dentition. Aim To evaluate the association between CM and DT at 4 years of age.
Renata Uliana Posser   +5 more
wiley   +1 more source

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