Application of cryopreservation to tooth germ transplantation for root development and tooth eruption [PDF]
Scientific Reports, 2021 We cryopreserved mouse tooth germs with widely open cervical margins of the enamel organ to overcome difficulties in cryoprotectant permeation and tested their efficacy by transplanting them into recipient mice. The upper right first molar germs of 8-day-
Xinghan Li +3 more
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Microstructured Hyaluronic Acid Hydrogel for Tooth Germ Bioengineering [PDF]
Gels, 2021 Tooth loss has been found to adversely affect not just masticatory and speech functions, but also psychological health and quality of life. Currently, teeth replacement options include dentures, bridges, and implants.
Sol Park +6 more
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Mouse Embryonic Tooth Germ Dissection and Ex vivo Culture Protocol [PDF]
Bio-Protocol, 2020 A tooth germ ex vivo organ culture allows visualization of its development in different stages, thus enabling investigation of the molecular mechanisms of regulatory factors.
Xue Han +5 more
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Self-Assembled Hydrogel Microparticle-Based Tooth-Germ Organoids [PDF]
Bioengineering, 2022 Here, we describe the characterization of tooth-germ organoids, three-dimensional (3D) constructs cultured in vitro with the potential to develop into living teeth.
Cemile Kilic Bektas +5 more
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The Secretome of the Inductive Tooth Germ Exhibits Signals Required for Tooth Development [PDF]
BioengineeringTeeth develop from reciprocal signaling between inductive and receptive cells. The inductive signals for tooth development are initially in the epithelium of the developing branchial arch, but later shift to the underlying mesenchyme of a developing ...
Anahid A Birjandi, Paul Sharpe
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Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study [PDF]
Regenerative TherapyObjectives: This study aimed to explore the potential of tooth germ stem cells for regenerating tooth-like structures by subcutaneously implanting first molar tooth germ stem cells over the masseter muscle in mice.
Nosrat Nourbakhsh +10 more
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RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development [PDF]
Frontiers in Physiology, 2017 Tooth development depends on multiple molecular interactions between the dental epithelium and mesenchyme, which are derived from ectodermal and ectomesenchymal cells, respectively.
Jun Yang +4 more
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Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ [PDF]
European Journal of Histochemistry, 2020 The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini +2 more
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Multiphoton microscopy imaging of developing tooth germs
Journal of the Formosan Medical Association, 2014 Traditionally, tooth germ is observed by histological investigation with hematoxylin and eosin stain and information may loss during the process. The purpose of this study is to use multiphoton laser fluorescence microscopy to observe the developing ...
Pei-Yu Pan +5 more
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Sonic Hedgehog Signaling and Development of the Dentition [PDF]
Journal of Developmental Biology, 2017 Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates.
Maisa Seppala +4 more
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