The Secretome of the Inductive Tooth Germ Exhibits Signals Required for Tooth Development [PDF]
BioengineeringTeeth develop from reciprocal signaling between inductive and receptive cells. The inductive signals for tooth development are initially in the epithelium of the developing branchial arch, but later shift to the underlying mesenchyme of a developing ...
Anahid A Birjandi, Paul Sharpe
doaj +5 more sources
Microstructured Hyaluronic Acid Hydrogel for Tooth Germ Bioengineering [PDF]
Gels, 2021 Tooth loss has been found to adversely affect not just masticatory and speech functions, but also psychological health and quality of life. Currently, teeth replacement options include dentures, bridges, and implants.
Sol Park +6 more
doaj +8 more sources
Mouse Embryonic Tooth Germ Dissection and Ex vivo Culture Protocol [PDF]
Bio-Protocol, 2020 A tooth germ ex vivo organ culture allows visualization of its development in different stages, thus enabling investigation of the molecular mechanisms of regulatory factors.
Xue Han +5 more
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Self-Assembled Hydrogel Microparticle-Based Tooth-Germ Organoids [PDF]
Bioengineering, 2022 Here, we describe the characterization of tooth-germ organoids, three-dimensional (3D) constructs cultured in vitro with the potential to develop into living teeth.
Cemile Kilic Bektas +5 more
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A deep learning approach to permanent tooth germ detection on pediatric panoramic radiographs. [PDF]
Imaging Sci Dent, 2022 Purpose The aim of this study was to assess the performance of a deep learning system for permanent tooth germ detection on pediatric panoramic radiographs.
Kaya E +5 more
europepmc +3 more sources
Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ [PDF]
European Journal of Histochemistry, 2020 The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini +2 more
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RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development [PDF]
Frontiers in Physiology, 2017 Tooth development depends on multiple molecular interactions between the dental epithelium and mesenchyme, which are derived from ectodermal and ectomesenchymal cells, respectively.
Jun Yang +4 more
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Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study [PDF]
Regenerative TherapyObjectives: This study aimed to explore the potential of tooth germ stem cells for regenerating tooth-like structures by subcutaneously implanting first molar tooth germ stem cells over the masseter muscle in mice.
Nosrat Nourbakhsh +10 more
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A Calcifying Odontogenic Cyst Associated with Compound Odontoma Mimicking a Tooth Germ. [PDF]
Case Rep Dent, 2021 Calcifying odontogenic cyst (COC) is a rare cyst that affects mainly the anterior region of the jaws. Generally, it appears as a unilocular radiolucent lesion containing peripheral foci of calcification, but with radiographic variations depending on the ...
Oliveira EM +3 more
europepmc +2 more sources
A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development. [PDF]
Cell Biosci, 2021 Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways.
Shi Y +7 more
europepmc +2 more sources