Results 41 to 50 of about 2,820,928 (238)

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

open access: yesAdvanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin   +6 more
wiley   +1 more source

Research for Tooth Profile Modification Technology and Slotting Process

open access: yes, 2011
The development status of profile modification technology and slotting process are described, the paper proposed slotting profile modification process, in view of the advantages of slotting processing.
Cong Gui Chen   +3 more
core   +1 more source

Influence of Tip Relief Profile Modification on Involute Spur Gear Stress [PDF]

open access: yes, 2016
This paper deals with the effects of linear tip profile modification on the stress of tooth root and tooth flank of involute spur gears. An increase in the tooth flank stress due to the tip profile modification is potentially hazardous because there is ...
Marković, Kristina, Vrcan, Željko
core   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

open access: yesAdvanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou   +11 more
wiley   +1 more source

Study on the Precise Modeling Method of Helical Gear with Deviation and Modification

open access: yesJixie chuandong, 2018
According to the forming process principle,the influence of the tooth profile modification,helix modification and tooth profile deviation,helix deviation and eccentricity tolerance of radial run-out of the involute helical gear on tooth profile shape is ...
Yuan Yongchao   +4 more
doaj  

Research on thermal characteristics of gear based on parametric tooth profile modification

open access: yesAdvances in Mechanical Engineering
This paper establishes a thermal analysis model for parametric profile modification gears based on the heat transfer mechanisms of gear transmission. The main research parameters are the addendum coefficient and the modification coefficient, focusing on ...
Hengzhe Shi, Wei Li, Wanlin Zhou
doaj   +1 more source

METHOD FOR MODIFYING PROFILE OF CYCLOIDAL WHEEL CONSIDERING COMPENSATION FOR ELASTIC DEFORMATION

open access: yesJixie qiangdu, 2020
Considering the influence of elastic deformation on the profile of the cycloid,a cycloid profile modification method for compensating elastic deformation is proposed.Based on the theory of cycloid profile modification,the coordinates of the meshing point
QIN ZhengZheng   +4 more
doaj  

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto   +5 more
wiley   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

open access: yesAnnals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate   +34 more
wiley   +1 more source

Two-parameter Envelope Calculation for the Profile of Worm Grinding Wheel and Dressing Method

open access: yesJixie chuandong, 2022
A mathematical model for tooth profile curve of cylinder gear with high-order modification gear surface is established. Applying two-parameter envelope theory to determine the meshing relationship between worm grinding wheel and helical gears,the ...
Shuai Wang   +5 more
doaj  

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