Results 131 to 140 of about 227,245 (293)

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

open access: yesMolecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang   +7 more
wiley   +1 more source

Development of an Integrated Computational Pipeline for PARP‐1 Inhibitor Screening Using Hybrid Virtual Screening and Molecular Dynamics Simulations

open access: yesChemistryOpen, EarlyView.
Poly(ADP‐ribose) polymerase 1 (PARP‐1) is vital for DNA repair. A computational workflow integrating AI‐driven virtual screening (TransFoxMol, KarmaDock, AutoDock Vina) and molecular dynamics identified novel PARP‐1 inhibitors with promising efficacy and minimized side effects.
Guan Wang   +3 more
wiley   +1 more source

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

open access: yesAging Cell, Volume 21, Issue 12, December 2022., 2022
This study shows that lifespan and healthspan parameters can be uncoupled and that the mitochondrial protein SIRT3 is a modulator of fuel utilization, physical activity, and aging. Abstract Mitochondrial NAD+‐dependent protein deacetylase Sirtuin3 (SIRT3) has been proposed to mediate calorie restriction (CR)‐dependent metabolic regulation and lifespan ...
Rashpal S. Dhillon   +11 more
wiley   +1 more source

Are public housing projects good for kids after all?

open access: yesJournal of Policy Analysis and Management, EarlyView.
Abstract Is public housing bad for children? The net effect of moving into public housing on children's academic outcomes is theoretically ambiguous and likely to depend on changes to neighborhood and school characteristics. Drawing on detailed individual‐level longitudinal data on New York City public school students, we exploit plausibly random ...
Jeehee Han, Amy Ellen Schwartz
wiley   +1 more source

Top-Down Online Handwritten Mathematical Expression Parsing with Graph Grammar [PDF]

open access: bronze, 2015
Frank Julca-Aguilar   +3 more
openalex   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca   +3 more
wiley   +1 more source

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