Results 61 to 70 of about 1,200,332 (267)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Method of Syntactic Analysis of Chinese Sentences on Topical Components
Научный диалог, 2018 The article is devoted to the syntactic analysis of sentences of isolating languages (Chinese), to the study of possible ways of such analysis based on various linguistic concepts, to the search for the most optimal variants.
K. E. Kotcik
doaj +1 more source
Journal of Dermatological Treatment, 2001 In this ever-expanding world of immunologic advancements, Drs Langley and Pearson have undertaken this timely, succinct review of imiquimod. Given its direct actions on monocytes and macrophages, as well as the many diverse cytokine effects that follow from these events, topical imiquimod has already solidly established itself as a successful treatment
G W, Pearson, R G, Langley
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Domain of interests clustering algorithm based on users’ preferred topics
Tongxin xuebao, 2011 In order to solve the problem of users’ preferences changing frequently,an iterative computing method was presented to gain the weights of users’ preferences as time goes.A bipartite graph was constructed to show the relations of users’ interests and ...
GONG Wei-hua1 +3 more
doaj
Discours, 2018 This paper attempts to describe how adverbs and adverbial expressions of manner and space came to function as discourse markers of topic shifting in contemporary Romanian and to sketch a possible typology of these markers.
Alice Ionescu, Cecilia-Mihaela Popescu
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
La focalisation des conditionnelles
Discours, 2014 The aim of this article is to identify the different syntactic modes existing in French to focus if-clauses in constructions such as {if-P, Q}, and {Q if-P}.
Gilles Corminboeuf
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source