Results 91 to 100 of about 52,118 (285)

US Farm Animal Welfare: An Economic Perspective

open access: yesAnimals, 2019
The topic of farm animal welfare (FAW) is both complex and controversial, and inherently involves expertise and views from multiple disciplines. This article provides a summary of economic perspectives on FAW issues in the United States.
Glynn T. Tonsor, Christopher A. Wolf
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Ekstraksi Frasa Kunci pada Penggabungan Klaster berdasarkan Maximum-Common-Subgraph

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi, 2018
Document clustering based on topic similarities helps users in searching from a collection of scientific articles. Topic labels are necessesary for describing subjects of the document clusters.
Adhi Nurilham   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Subject/non-subject movement asymmetries in Late Archaic Chinese

open access: yesGlossa, 2019
This paper accounts for the inability of a non-subject DP to move over the subject in Late Archaic Chinese (LAC) by proposing that DP movement could only be licensed by checking a case feature.
Edith Aldridge
doaj   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

The “label code” of pro-environmental behavior—a study on pro-environmental behavior based on behavioral label theory

open access: yesScientific Reports
The topic of environmental protection has received more and more attention, among which pro-environmental behavior is a major focus of attention. Based on the findings of construal level theory, behavioral labels, and personal norms, combined with the ...
Xiaozhi Huang, Jiayue Li
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

VISTA: A Multi-View, Hierarchical, and Interpretable Framework for Robust Topic Modelling

open access: yesMachine Learning and Knowledge Extraction
Topic modeling is a fundamental technique in natural language processing used to uncover latent themes in large text corpora, yet existing approaches struggle to jointly achieve interpretability, semantic coherence, and scalability.
Tvrtko Glunčić   +2 more
doaj   +1 more source

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