Results 111 to 120 of about 17,652,183 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Empirical Comparison of Word Similarity Measures Based on Co-Occurrence, Context, and a Vector Space Model

Journal of Information Science Theory and Practice, 2020
Word similarity is often measured to enhance system performance in the information retrieval field and other related areas. This paper reports on an experimental comparison of values for word similarity measures that were computed based on 50 ...
Natsuki Kadowaki, Kazuaki Kishida
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cross-Domain Explainable Recommendation Using Graph Convolutional Networks and a Topic Model

IEEE Access
Graph Convolutional Network (GCN)-based recommendation systems (RSs) have recently gained popularity for their ability to improve recommendation accuracy by utilizing neighborhood information in user-item interaction graphs.
Kunyoung Kim, Mye Sohn, Jongmo Kim
doaj   +1 more source

TCMHG: Topic-Based Cross-Modal Hypergraph Learning for Online Service Recommendations

IEEE Access, 2018
Online product reviews sentiment classification plays an important role on service recommendation, yet most of current researches on it only focus on single-modal information ignoring the complementary information, that results in unsatisfied accuracy of
Zhikui Chen, Fei Lu, Xu Yuan, Fangming Zhong   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Hybrid Approach to Recognising Activities of Daily Living from Object Use in the Home Environment

Informatics, 2018
Accurate recognition of Activities of Daily Living (ADL) plays an important role in providing assistance and support to the elderly and cognitively impaired.
Isibor Kennedy Ihianle, Usman Naeem, Syed Islam, Abdel-Rahman Tawil   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Topic Modeling in Marathi

CoRR
While topic modeling in English has become a prevalent and well-explored area, venturing into topic modeling for Indic languages remains relatively rare. The limited availability of resources, diverse linguistic structures, and unique challenges posed by Indic languages contribute to the scarcity of research and applications in this domain. Despite the
Sanket Shinde, Raviraj Joshi
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source