Results 141 to 150 of about 17,652,183 (292)

Quality indices for topic model selection and evaluation: a literature review and case study. [PDF]

BMC Med Inform Decis Mak, 2023
Meaney C, Stukel TA, Austin PC, Moineddin R, Greiver M, Escobar M.   +5 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

<i>Turtling</i>: a time-aware neural topic model on NIH grant data. [PDF]

Bioinform Adv, 2023
Zhang R, Duan Z, Lee C, Riffle D, Min MR, Zhang J.   +5 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Continuous-time infinite dynamic topic models [PDF]

Doctor of PhilosophyDepartment of Computing and Information SciencesWilliam Henry HsuTopic models are probabilistic models for discovering topical themes in collections of documents.
Elshamy, Wesam Samy
core  

New interest-sensitive and network-sensitive method for user recommendation

Tongxin xuebao, 2015
A new hybrid approach by incorporatin gusers’ interests and users’ friendships together to recommend new friends for target users is proposed.A variation of PageRank—Topic_Friend_PageRank(TFPR) is proposed,which can consider user interests and user ...
Yan-min SHANG, Peng ZHANG, Ya-nan CAO
doaj  

Analyzing Alzheimer’s Disease Research Trends: Insights From Improved Dynamic Topic Modeling

IEEE Access
This study addresses the need for a comprehensive understanding of evolving research trends and challenges in Alzheimer’s disease research literature from 2016 to 2023. Employing an improved Dynamic Topic Model (DTM), we analyze the landscape from
Juan Shen, Vladimir Y. Mariano
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Design and implementation of spam filtering system based on topic model

Dianxin kexue, 2017
Spam filtering technology plays a key role in many areas including information security,transmission efficiency,and automatic information classification.However,the emergence of spam affects the user's sense of experience,and can cause unnecessary ...
Xiaohuai KOU, Hua CHENG
doaj  

Retracted: SDTM: A Novel Topic Model Framework for Syndrome Differentiation in Traditional Chinese Medicine. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source