Results 161 to 170 of about 814,278 (307)

New interest-sensitive and network-sensitive method for user recommendation

open access: yesTongxin xuebao, 2015
A new hybrid approach by incorporatin gusers’ interests and users’ friendships together to recommend new friends for target users is proposed.A variation of PageRank—Topic_Friend_PageRank(TFPR) is proposed,which can consider user interests and user ...
Yan-min SHANG, Peng ZHANG, Ya-nan CAO
doaj  

Analyzing Alzheimer’s Disease Research Trends: Insights From Improved Dynamic Topic Modeling

open access: yesIEEE Access
This study addresses the need for a comprehensive understanding of evolving research trends and challenges in Alzheimer’s disease research literature from 2016 to 2023. Employing an improved Dynamic Topic Model (DTM), we analyze the landscape from
Juan Shen, Vladimir Y. Mariano
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Design and implementation of spam filtering system based on topic model

open access: yesDianxin kexue, 2017
Spam filtering technology plays a key role in many areas including information security,transmission efficiency,and automatic information classification.However,the emergence of spam affects the user's sense of experience,and can cause unnecessary ...
Xiaohuai KOU, Hua CHENG
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Topic 2: performance prediction and evaluation

open access: yes, 2013
In recent years, a range of novel methodologies and tools have been developed for the purpose of evaluation, design, and model reduction of existing and emerging parallel and distributed systems.
Getov, Vladimir   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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