Results 111 to 120 of about 2,400 (301)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

open access: yesAdvanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun   +12 more
wiley   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi   +22 more
wiley   +1 more source

Syntactic Analysis of Topicalization in Ikwuano Igbo

open access: yes
The aim of this paper 'Syntactic Analysis of Topicalization in IkwuanoIgbo' is to examine topicalization in Ikwuano, with a view toestablishing the Ikwuano strategy.
Uwasomba Ph.D, Blessing Ugochi
core  

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

open access: yesAdvanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola   +10 more
wiley   +1 more source

On the topic of topic and topic continuity

open access: yesling, 1992
PETER SCHLOBINSKI   +1 more
openaire   +1 more source

Topic resumption in Bamiléké Ngemba: Animate/inanimate asymmetries and strictly local Impoverishment

open access: yesGlossa
Ngemba displays an interesting asymmetry in topicalization. Unlike subject topics, which are always resumed, object topics can only be resumed if the topic XP is animate.
Leonel Tadjo Fongang
doaj   +2 more sources

Subjacency and Japanese Grammar

open access: yes, 1996
It has been claimed by Hasegawa, Yoshimura, Nishigauchi, Kikuchi, Saito and Watanabe, among others, that Japanese observes subjacency in relative clause formation, question formation, topicalization, comparative deletion (all non-overt operator movements)
John H. Haig
core   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan   +12 more
wiley   +1 more source

Determiner sharing in German by clausal ellipsis and split topicalization

open access: yes
In determiner sharing, a quantifier may be omitted from a coordination in the context of another ellipsis. This paper proposes a novel analysis on the basis of new German data: determiner sharing arises from the interaction of clausal ellipsis and split ...
Schwarzer, Luise
core   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng   +4 more
wiley   +1 more source

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