Results 81 to 90 of about 2,400 (301)

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

open access: yesAdvanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li   +9 more
wiley   +1 more source

How to agree with a QNP

open access: yesGlossa, 2019
This paper focuses on the great variety of φ-agreement patterns and case alternations quantified noun phrases trigger in Serbo-Croatian. Novel data from Serbo-Croatian are contributed, showing more agreement patterns than so far attested. Crucial for the
Imke Driemel, Jelena Stojković
doaj   +2 more sources

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

open access: yesAdvanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou   +14 more
wiley   +1 more source

The Interaction of Topicalization and Left-Dislocation in English

open access: yesAnglophonia, 2019
Topicalization (TOP) in English requires that the topicalized information stand in a partially-ordered set (poset) relationship with previously evoked information, whereas Left-Dislocation (LD) has been argued to have three discourse functions: to ...
Betty J. Birner, Gregory Ward
doaj   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

open access: yesAdvanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu   +12 more
wiley   +1 more source

Japanese ECM as Embedded Bare Topicalization

open access: yes, 2015
Proceedings of the 38th Meeting of the North East Linguistic Society. Ottawa, CA, 2007-10-26/28, University of Ottawa.Articleapplication/pdf“Japanese ECM as Embedded Bare Topicalization”.
Taguchi, Shigeki
core  

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

open access: yesAdvanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran   +10 more
wiley   +1 more source

Topicalization

open access: yes
In CA/IL research, topicalization can be conceptualized in both sequence-organizational and grammatical ...
Luis Manuel Olguín
core   +1 more source

Japanese ECM as Embedded Bare Topicalization [PDF]

open access: yes
Proceedings of the 38th Meeting of the North East Linguistic Society. Ottawa, CA, 2007-10-26/28, University of Ottawa.Article“Japanese ECM as Embedded Bare Topicalization”. Proceedings of the 38th Meeting of the North East Linguistic Society. Ottawa, CA,
Taguchi, Shigeki
core  

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