Dual role of topoisomerase II in centromere resolution and aurora B activity.
PLoS Biology, 2008 Chromosome segregation requires sister chromatid resolution. Condensins are essential for this process since they organize an axial structure where topoisomerase II can work. How sister chromatid separation is coordinated with chromosome condensation and
Paula A Coelho +5 more
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Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
Journal of Nucleic Acids, 2010 The role of topoisomerase IIβ was investigated in cell lines exposed to two DNA damaging agents, ionising radiation (IR) or etoposide, a drug which acts on topoisomerase II. The appearance and resolution of γH2AX foci in murine embryonic fibroblast cell
Nicola J. Sunter +4 more
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Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
PLoS ONE, 2014 DNA topoisomerases are enzymes responsible for the relaxation of DNA torsional strain, as well as for the untangling of DNA duplexes after replication, and are important cancer drug targets.
Malgorzata N Drwal +5 more
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A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]
, 2010 Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core +2 more sources
Química Nova, 2012 Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA.
Amanda de Melo Bezerra +8 more
doaj +1 more source
Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents
Molecules, 2019 To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors.
Ming-Jie Chu +8 more
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The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide. [PDF]
PLoS ONE, 2013 The mixed lineage leukaemia (MLL) gene is frequently rearranged in secondary leukaemias, in which it could fuse to a variety of different partners.
Sergey I Glukhov +5 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2019 Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Clear cell RCC (ccRCC) accounts for the majority of RCC, which have mutations or epigenetic silencing of the von Hippel–Lindau (VHL) gene.
Hiromi Koma +3 more
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Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases [PDF]
, 2010 ype II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage complex with a gate-DNA duplex that allows transport of a ...
Laponogov, I +27 more
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Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases [PDF]
, 2007 Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase ...
GIARETTA G +15 more
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