Results 31 to 40 of about 87,231 (262)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Flux quantization on M5-branes

Journal of High Energy Physics
We highlight the need for global completion of the field content in the M5-brane sigma-model analogous to Dirac’s charge/flux quantization, and we point out that the superspace Bianchi identities on the worldvolume and on its ambient supergravity ...
Grigorios Giotopoulos, Hisham Sati, Urs Schreiber   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Topological nodal-line fermions in spin-orbit metal PbTaSe2

Nature Communications, 2016
Nodal-line shaped bands appearing near the Fermi level host unique properties in topological matter, which has yet to be confirmed in real materials.
Guang Bian, Tay-Rong Chang, Raman Sankar, Su-Yang Xu, Hao Zheng, Titus Neupert, Ching-Kai Chiu, Shin-Ming Huang, Guoqing Chang, Ilya Belopolski, Daniel S. Sanchez, Madhab Neupane, Nasser Alidoust, Chang Liu, BaoKai Wang, Chi-Cheng Lee, Horng-Tay Jeng, Chenglong Zhang, Zhujun Yuan, Shuang Jia, Arun Bansil, Fangcheng Chou, Hsin Lin, M. Zahid Hasan   +23 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

[5,10,15,20-Tetrakis(pentafluorophenyl)porphyrinato]zinc(II) benzene disolvate

IUCrData, 2020
Single crystals of the title zinc porphyrinato complex, [Zn(C44H8F20N4)]·2C6H6, were obtained by the solvent evaporation method. The molecular complex exhibits point group symmetry \overline1 with the central ZnII atom located on an inversion centre. The
Zeyuan Lin, Jianfeng Li
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Signatures of the Adler–Bell–Jackiw chiral anomaly in a Weyl fermion semimetal

Nature Communications, 2016
Anomalous conducting behavior of solids may reflect the presence of novel quantum states. Here, Zhang et al. report an increased conductivity in TaAs with a magnetic field applied along the direction of the current, which reveals an inherent property of ...
Cheng-Long Zhang, Su-Yang Xu, Ilya Belopolski, Zhujun Yuan, Ziquan Lin, Bingbing Tong, Guang Bian, Nasser Alidoust, Chi-Cheng Lee, Shin-Ming Huang, Tay-Rong Chang, Guoqing Chang, Chuang-Han Hsu, Horng-Tay Jeng, Madhab Neupane, Daniel S. Sanchez, Hao Zheng, Junfeng Wang, Hsin Lin, Chi Zhang, Hai-Zhou Lu, Shun-Qing Shen, Titus Neupert, M. Zahid Hasan, Shuang Jia   +24 more
doaj   +1 more source