Results 41 to 50 of about 87,231 (262)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Superconductivity and a van Hove singularity confined to the surface of a topological semimetal

Nature Communications
The interplay between topology and superconductivity generated great interest in condensed matter physics. Here, we unveil an unconventional two-dimensional superconducting state in the Dirac nodal line semimetal ZrAs2 which is exclusively confined to ...
Md Shafayat Hossain, Rajibul Islam, Zi-Jia Cheng, Zahir Muhammad, Qi Zhang, Zurab Guguchia, Jonas A. Krieger, Brian Casas, Yu-Xiao Jiang, Maksim Litskevich, Xian P. Yang, Byunghoon Kim, Tyler A. Cochran, Ilias E. Perakis, Thomas Hicken, Hubertus Luetkens, Fei Xue, Mehdi Kargarian, Weisheng Zhao, Luis Balicas, M. Zahid Hasan   +20 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Realization of large-area ultraflat chiral blue phosphorene

Nature Communications
Blue phosphorene (BlueP), a theoretically proposed phosphorous allotrope with buckled honeycomb lattice, has attracted considerable interest due to its intriguing properties.
Ye-Heng Song, M. U. Muzaffar, Qi Wang, Yunhui Wang, Yu Jia, Ping Cui, Weifeng Zhang, Xue-Sen Wang, Zhenyu Zhang   +8 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Physics-informed convolutional neural networks for fluid flow through porous media

Scientific Reports
Accurate simulation of fluid flow in porous media is a challenging task due to the complexity of pore-space geometries and the computational cost of solving the Navier–Stokes equations.
Rafał Topolnicki, Paweł Dłotko, Maciej Matyka   +2 more
doaj   +1 more source

Crystal structure of bis(1-ethyl-1H-imidazole-κN3)(meso-tetramesitylporphyrinato-κ4N,N′,N′′,N′′′)iron(III) perchlorate chlorobenzene sesquisolvate

IUCrData, 2019
In the complex cation of title compound, [Fe(C56H52N4)(C5H8N2)2]ClO4·1.5C6H5Cl, the ironIII atom is coordinated in a distorted octahedral manner by four pyrrole N atoms of the porphyrin ring system in the equatorial plane, and by two N atoms of the 1 ...
Nana Zhan, Haimang Wang, Jianfeng Li
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

The M-algebra completes the hierarchy of super-exceptional tangent spaces

Physics Letters B
The conjectured symmetries of M-theory famously involve (1.) brane-extended super-symmetry (the M-algebra) and (2.) exceptional duality symmetry (the e11-algebra); but little attention has been given to their inevitable combination.In this short note, we
Grigorios Giotopoulos, Hisham Sati, Urs Schreiber   +2 more
doaj   +1 more source

Nexus fermions in topological symmorphic crystalline metals

Scientific Reports, 2017
Topological metals and semimetals (TMs) have recently drawn significant interest. These materials give rise to condensed matter realizations of many important concepts in high-energy physics, leading to wide-ranging protected properties in transport and ...
Guoqing Chang, Su-Yang Xu, Shin-Ming Huang, Daniel S. Sanchez, Chuang-Han Hsu, Guang Bian, Zhi-Ming Yu, Ilya Belopolski, Nasser Alidoust, Hao Zheng, Tay-Rong Chang, Horng-Tay Jeng, Shengyuan A. Yang, Titus Neupert, Hsin Lin, M. Zahid Hasan   +15 more
doaj   +1 more source