Results 51 to 60 of about 50,858 (315)
Automated Derivation of Use Case Model from Topological Functioning Model
Scientific Journal of Riga Technical University. Computer Sciences, 2011 Automated Derivation of Use Case Model from Topological Functioning ModelThe first important step in Model Driven Architecture software development is qualitative analysis and specification of structure and behavior of business and its supporting information system as well as software requirements.
Timofejs Murenecs, Erika Asnina
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Local stability properties of complex, species‐rich soil food webs with functional block structure
Ecology and Evolution, 2021 Ecologists have long debated the properties that confer stability to complex, species‐rich ecological networks. Species‐level soil food webs are large and structured networks of central importance to ecosystem functioning.
Francisco deCastro +18 more
doaj +1 more source
Brain network reorganization after targeted attack at a hub region
NeuroImage, 2021 The architecture of brain networks has been extensively studied in multiple species. However, exactly how the brain network reconfigures when a local region, particularly a hub region, stops functioning remains elusive.
Wenyu Tu, Zilu Ma, Nanyin Zhang
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The Food Web of Potter Cove (Antarctica): complexity, structure and function [PDF]
, 2018 Knowledge of the food web structure and complexity are central to better understand ecosystem functioning. A food-web approach includes both species and energy flows among them, providing a natural framework for characterizing species’ ecological roles ...
Barrera Oro, Esteban +14 more
core +2 more sources
Complex delay dynamics on railway networks: from universal laws to realistic modelling
, 2018 Railways are a key infrastructure for any modern country. The reliability and resilience of this peculiar transportation system may be challenged by different shocks such as disruptions, strikes and adverse weather conditions. These events compromise the
di Clemente, Riccardo +3 more
core +3 more sources
Frontiers in Materials, 2020 A precise structural organization of epithelial cells is needed for the proper functioning and development of different tissues. The epithelial cell packing mechanism is associated with mechanical interactions between cells that place the tissue in a ...
Rene Markovič +6 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecules, 2023 Human soluble epoxide hydrolase (sEH), a dual-functioning homodimeric enzyme with hydrolase and phosphatase activities, is known for its pivotal role in the hydrolysis of epoxyeicosatrienoic acids.
Shuvam Sar +6 more
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Brazilian Journal of Medical and Biological Research, 2022 The study of functional reorganization following stroke has been steadily growing supported by advances in neuroimaging techniques, such as functional magnetic resonance imaging (fMRI). Concomitantly, graph theory has been increasingly employed in neuroscience to model the brain's functional connectivity (FC) and to investigate it in a variety of ...
S.R.M. Almeida +6 more
openaire +5 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source