Results 161 to 170 of about 117,051,059 (274)

Atypical development of white matter structural networks in children and adolescents with autism spectrum disorder: a graph theory study. [PDF]

Front Neurosci
Li M, Kurita K, Yamada T, Wang Y, Izumoto M, Iwatani Y, Mohri I, Shou Q, Yamashita M, Hamatani S, Matsuzaki H, Okazawa H, Yoshida T, Kitagawa H, Sasaki T, Matsumoto K, Nagano T, Isobe Y, Kamashita R, Sudo Y, Shimizu E, Kawasaki R, Hirano Y, Mizuno Y, Kagitani-Shimono K.   +24 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

QSPR modeling of physicochemical properties of SSRI and SNRI antidepressants using advanced molecular graph descriptors. [PDF]

Sci Rep
Kabeer A, Mufti ZS, Almehizia AA, Assiri AA, Ganati GA.   +4 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Fractal hierarchy enables exponential scaling of topological boundary states. [PDF]

Nat Commun
Song L, Hu Z, Wang Z, Bongiovanni D, Tang L, Song D, Morandotti R, Xu J, Buljan H, Chen Z.   +9 more
europepmc   +1 more source

Stochastic Entanglement of Deterministic Origami Tentacles For Robust Robotic Grasping

Advanced Science, EarlyView.
This study introduces an origami tentacle gripper to robustly grasp objects‐in air, underwater, and even in orbital space‐by exploiting a synergy between local, deterministic deformation programming and global, stochastic entanglements. A single origami tentacle can be designed to coil with a simple tendon pull.
Alec Boron, Bokun Zheng, Ziyang Zhou, Noel Naughton, Suyi Li   +4 more
wiley   +1 more source

Interaction topology theory deciphers multiscale codes of MOF-like materials. [PDF]

Sci Adv
Chen D, Liu J, Chen CL, Wei GW.
europepmc   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

Disrupted Functional Brain Network Topology in Etomidate Misuse. [PDF]

Alpha Psychiatry
Tang Y, Wang X, Le J, Huang Q, Chen H, Chen X, Wang X, Tang Y, Zhao L, Zhao L, Shen H, Liao Z.   +11 more
europepmc   +1 more source

Topological Data Analysis-Driven fNIRS Signal Processing for Alzheimer's Disease Stage Identification. [PDF]

Sensors (Basel)
Liu S, Wu H, Sun C, Qiu Y, Wu H, Wei Y, Lv Y, Yang Z.   +7 more
europepmc   +1 more source