Results 171 to 180 of about 117,051,059 (274)

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Charting higher-order models of brain function beyond pairwise interactions. [PDF]

Nat Commun
Santoro A, Neri M, Poetto S, Orsenigo D, Diano M, Gatica M, Petri G.   +6 more
europepmc   +1 more source

Thermal Control of Concentric Topographies Patterned by Dynamic Electro‐Templated Generated Chiral Solitonic Structures

Advanced Science, EarlyView.
An electro‐templating strategy directs the relaxation of cholesteric finger loops into discrete concentric rings whose geometry is electrically programmed. The photopolymerized structures retain the topological defect pattern and, upon heating, show reversible, castle‐like surface modulation.
Jacques A. Peixoto, Hanqing Zhao, Dirk J. Broer, Ivan I. Smalyukh, Danqing Liu   +4 more
wiley   +1 more source

Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study. [PDF]

Front Aging Neurosci
Yan Q, Wang Y, Xu L, Liu B, Zhu B, Shang S, Guan B.   +6 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Topological Insulator Materials for High-Performance Microwave Absorption: A Comprehensive Review on Mechanisms and Design Strategies. [PDF]

Small
Li ZX, Bi S, Li H, Zhou YT, Meng R, Zhang JY, Hou ZL.   +6 more
europepmc   +1 more source

A Covalent Organic Framework With Staggered Topology for Mimetic Transmembrane Transport of Hydrated Ions

Advanced Science, EarlyView.
Inspired by biological ion channels, an AB‐staggered β‐ketoenamine‐linked COF enables rapid hydrated‐ion transport through a biomimetic dehydration‐compensation mechanism, where carbonyl‐rich convergent channels partially offset ion dehydration energy. As aqueous Zn battery separators, the COF membranes suppress parasitic reactions and dendrite growth,
Xuan Li, Jiaxin Liu, Yilin Zhang, Zhixiang Dai, Zihan Tan, Hongli Yang, Chao Xu, Shengyang Zhou, Zhong‐Ming Li   +8 more
wiley   +1 more source

Redefining topological robustness in optical polarization fields through a generalized skyrmion number. [PDF]

Nat Commun
Wang AA, Ma Y, Zhao Z, Cai Y, Morris SM, He H, Xie Z, Shi P, Shen Y, Zayats AV, Yuan X, He C.   +11 more
europepmc   +1 more source

Engineering Ultrastable Intrinsic Radicals: Graphene Quantum Dots With NIR‐II Emission for Dynamic Deep‐Tissue Bioimaging

Advanced Science, EarlyView.
Stable radicals are attractive for photonic and quantum information technologies but are often limited by instability. We stabilize intrinsic radicals in graphene quantum dots via 2D polymerization of perylene derivatives, where bilayer defect confinement suppresses quenching (100–500 K).
Qin Xu, Yijie Hou, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Shuaiqi Li, Maohua Chen, Guichuan Xing, Dongbo Guo, Songnan Qu   +9 more
wiley   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source