Results 41 to 50 of about 244,971 (312)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Pairwise Compact In Intuitionistic Double Topological Spaces

Journal of Kufa for Mathematics and Computer, 2011
The concept of intuitionistic topological space was introduced by Çoker .The aim of this paper is to discuss the relation between  bitopological spaces and double- topological spaces and give a notion of pairwise compact for double topological spaces .
Hadi J Mustafa, Rewayda Razaq Mohsin, Enas Yehya Abdullah   +2 more
doaj   +1 more source

On soft submaximal spaces

Heliyon, 2022
In the present paper, detailed properties of soft submaximal topological spaces have been discussed. It starts by examining how well soft submaximal spaces behave when subjected to some operations, such as: taking soft subspaces, soft products, soft ...
Samer Al Ghour, Zanyar A. Ameen
doaj   +1 more source

Derivational modal logics with the difference modality

, 2014
In this chapter we study modal logics of topological spaces in the combined language with the derivational modality and the difference modality. We give axiomatizations and prove completeness for the following classes: all spaces, $T_1$-spaces, dense-in ...
Kudinov, Andrey, Shehtman, Valentin
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Products on Maximal Compact Frames

Ratio Mathematica, 2023
In topological spaces, many topological properties such as separation properties, paracompactness etc. are preserved under the act of taking product of topological spaces.
Jayaprasad P. N.
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu, Yongsheng Wu, Junyu Qu, Rui Zhu, Wenwen Xu, Jiaxiang Xin, Dawei Wang   +6 more
wiley   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Spectral Radii of Bounded Operators on Topological Vector Spaces [PDF]

, 2000
In this paper we develop a version of spectral theory for bounded linear operators on topological vector spaces. We show that the Gelfand formula for spectral radius and Neumann series can still be naturally interpreted for operators on topological ...
Troitsky, Vladimir G.
core