Results 141 to 150 of about 404,403 (255)

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Exploring the Potential Anticancer Effects of Lobelia chinensis Lour in Liver Cancer via Multiomics Analysis

Med Research, EarlyView.
The incidence and mortality of liver cancer remain consistently high worldwide, with China particularly affected. To identify potential therapeutic components and elucidate their mechanisms of action, this study performed a comprehensive multiomics analysis based on the active ingredients of LCL.
Zixuan Yang, Li Song, Hongru Chen, Yaoyao Chen, Youyi Xie, Jumin Xie   +5 more
wiley   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

On the Relation Between Open and Closed Topological Strings [PDF]

, 2004
Anton Kapustin, Lev Rozansky
openalex   +3 more sources

Large N instantons from topological strings

SciPost Physics
The $1/N$ expansion of matrix models is asymptotic, and it requires non-perturbative corrections due to large $N$ instantons. Explicit expressions for large $N$ instanton amplitudes are known in the case of Hermitian matrix models with one cut, but not ...
Marcos Mariño, Ramon Miravitllas
doaj   +1 more source

Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations

ChemistryOpen, EarlyView.
A systematic computational workflow integrates Protein–Ligand Affinity prediction NETwork (PLANET), a GPU‐accelerated version of AutoDock Vina (Vina‐GPU), molecular mechanics/generalized born surface area (MM/GBSA), absorption distribution metabolism excretion toxicity prediction (admetSAR 3.0), molecular dynamics (MD), and absolute binding free energy
Xi Chen, Xinle Yang, Roufen Chen, Lei Xu, Xiaowu Dong, Zhen Cai   +5 more
wiley   +1 more source

Quantum curves as quantum distributions

Journal of High Energy Physics, 2019
Topological strings on toric Calabi-Yau threefolds can be defined non-perturbatively in terms of a non-interacting Fermi gas of N particles. Using this approach, we propose a definition of quantum mirror curves as quantum distributions on phase space ...
Marcos Mariño, Szabolcs Zakany
doaj   +1 more source

Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications

PROTEOMICS, EarlyView.
ABSTRACT Protein function is dynamically modulated by post‐translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. It is well known that many PTMs have an effect on protein function and cellular processes, and they should be studied not in isolation, but in the
Julian Müller, Bernhard Kuster, Matthew The   +2 more
wiley   +1 more source

Toward Useful Quantum Kernels

Advanced Quantum Technologies, EarlyView.
The hybrid approach to Quantum Supervised Machine Learning is compatible with Noisy Intermediate Scale Quantum (NISQ) devices but hardly useful. Pure quantum kernels requiring fault‐tolerant quantum computers are more promising. Examples are kernels computed by means of the Quantum Fourier Transform (QFT) and kernels defined via the calculation of ...
Massimiliano Incudini, Francesco Martini, Alessandra Di Pierro   +2 more
wiley   +1 more source

Computing the elliptic genus of higher rank E-strings from genus 0 GW invariants

Journal of High Energy Physics, 2019
We show that the elliptic genus of the higher rank E-strings can be computed based solely on the genus 0 Gromov-Witten invariants of the corresponding elliptic geometry.
Zhihao Duan, Jie Gu, Amir-Kian Kashani-Poor   +2 more
doaj   +1 more source