Results 141 to 150 of about 327,247 (251)

Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo, Gan Tao, Mini Zhang, Linzhi Han, Sisi Yan, Chunsheng Wang, Jianguo Zhang, Xiaowan Guo, Kehua Hu, Yan Gong, Qiuji Wu, Conghua Xie   +11 more
wiley   +1 more source

Borel singularities and Stokes constants of the topological string free energy on one-parameter Calabi-Yau threefolds

Journal of High Energy Physics
We study the Borel plane of the topological string free energy on all hypergeometric one-parameter Calabi-Yau models close to singular points in moduli space, focusing on the location of Borel singularities and the value of the associated Stokes ...
Simon Douaud, Amir-Kian Kashani-Poor
doaj   +1 more source

Cosmic necklaces in string theory and field theory [PDF]

, 2010
PhDIn this thesis we investigate astrophysical phenomena which arise in models with compact extra dimensions, focussing on the cosmological consequences of strings which wrap cycles in the internal space. Embedding our strings in the Klebanov-Strassler
Lake, Matthew James
core  

Smart molecular design of NIR‐II organic fluorophores through self‐driven iterative evolution, deep learning, and fragment‐based assembly

Smart Molecules, EarlyView.
A smart design strategy for NIR‐II organic fluorophores is proposed by combining self‐driven Iterative evolution, deep Learning, and fragment‐based assembly. This work establishes a broadly applicable approach for molecular design, accelerating the discovery of NIR‐II fluorophores and extending to optoelectronic materials and therapeutic compounds ...
Yu Zhang, Zhubin Hu, Xinyuan Wang, Zhenrong Sun, Yongye Liang, Cheng Zhong, Haitao Sun   +6 more
wiley   +1 more source

Cosmic microwave anisotropies from BPS semilocal strings

, 2008
We present the first ever calculation of cosmic microwave background (CMB) anisotropy power spectra from semilocal cosmic strings, obtained via simulations of a classical field theory.
Martin Kunz (1271922), Jon Urrestilla (16040027), Mark Hindmarsh (4460551), Andrew Liddle (16042793), Neil Bevis (16058051)   +4 more
core   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Addressing Long‐Tailed Drug–Drug Interactions Through Minimisation of Predictive Uncertainty and Loss Sharpness

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Drug–Drug Interaction (DDI) prediction is critical for ensuring patient safety, particularly under long‐tailed distributions, where frequent (head) interactions dominate whereas rare (tail) interactions remain underrepresented. Conventional loss functions such as cross‐entropy often tend to overfit head classes while they underperform on rare ...
Chao Liu, Xizhao Wang, Farhad Pourpanah, Sam Kwong   +3 more
wiley   +1 more source

Temperature Extraction Scheme for Composite Insulator Core Rod Sheath of Overhead Transmission Lines Based on Oriented Bounding Boxes

High Voltage, EarlyView.
ABSTRACT Unmanned Aerial Vehicle (UAV) inspection of overhead transmission line composite insulators allows for the rapid acquisition of large amounts of infrared images of insulators in service, which can be used to analyse their operational status. However, efficiently and accurately analysing these images remains a challenge.
Zhenan Zhou, Xinzhe Yu, Yu Deng, Chen Gu, Kun Zhang, Zheyuan Liu, Songsong Zhou, Yueneng Xu   +7 more
wiley   +1 more source

Machine Learning‐Assisted Development in Insulating Materials for High Voltage Applications

High Voltage, EarlyView.
ABSTRACT The advancement of power systems imposes increasingly stringent performance requirements on insulating materials, making the development of high‐performance insulating materials a critical challenge in the field of electrical engineering. Traditional material development relies heavily on empirical trial‐and‐error approaches, which are time ...
Yichen Ran, Yi Wang, Changheng Li, Jingyu Deng, Jian Wang, Haochen Zuo, Chen Zhao, Qian Wang, Yi Li, Song Xiao, Zhengyong Huang, Chao Wu, Zhonghui Shen, Kunming Shi, Fei Liu, Jie Chen, Jian Li, Xingyi Huang   +17 more
wiley   +1 more source

Les Houches lectures on matrix models and topological strings

, 2004
In these lecture notes for the Les Houches School on Applications of Random Matrices in Physics we give an introduction to the connections between matrix models and topological strings.
Marino, M
core