Results 201 to 210 of about 327,247 (251)
Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1913-1927, October 2026.The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen +7 more
wiley +1 more source
Testing for Genetic Interactions in Complex Disease With Distance Correlation
Biometrical Journal, Volume 68, Issue 5, October 2026.ABSTRACT Understanding epistasis (genetic interaction) may shed some light on the genomic basis of common diseases, including disorders of maximum interest due to their high socioeconomic burden, like schizophrenia. Distance correlation is an association measure that characterizes general statistical independence between random variables, not only the ...
Fernando Castro‐Prado +4 more
wiley +1 more source
GraphTransDTI: A novel hybrid framework combining graph transformer and CNN-BiLSTM for enhanced Drug-Protein Interaction prediction. [PDF]
PLoS OneLe VV, Nhu MTA, Thong PTV.
europepmc +1 more source
CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Background Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and ...
Lixue Cao +10 more
wiley +1 more source
Entropic Phenomena in Spin-Ice Materials and Magnetic Monopole Excitations. [PDF]
Entropy (Basel)Chappa A, Miao L.
europepmc +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Three new alkaloids, colombiains A–C (1–3), together with eight known ones (4–11) were isolated from the soft coral‐derived fungus Cladosporium colombiae CSGL 10M10. Compounds 6 and 11 exhibited significant cardioprotective activity against OGD/R‐induced injury in H9c2 cardiomyocytes at 10 µM.
Jing Xie +8 more
wiley +1 more source
MEGH-DDI: MolT5-driven edge-aware graph learning with Hop2Token representation for drug-drug interaction prediction. [PDF]
PLoS Comput BiolZhou L, Zuo Y, He W, Deng Z.
europepmc +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley +1 more source
Learning a chemistry-aware latent space for molecular encoding and generation with a large-scale transformer variational autoencoder. [PDF]
J CheminformTalibart H, Gilis D.
europepmc +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Bioassay‐guided fractionation of Zanthoxylum armatum fruits identifies three bioactive lignans—sesamin, fargesin, and eudesmin. The identified lignans attenuate CpG‐induced dendritic‐cell activation by reducing IL‐12 expression and CD80. Network pharmacology and molecular docking suggest involvement of multiple inflammatory signalling pathways ...
Ningthoujam Indrajit Singh +3 more
wiley +1 more source