Results 201 to 210 of about 935 (235)

From Stability to Chaos: A Complete Classification of the Damped Klein‐Gordon Dynamics

open access: yesMathematical Methods in the Applied Sciences, Volume 49, Issue 9, Page 9696-9708, June 2026.
ABSTRACT We investigate the transition between stability and chaos in the damped Klein‐Gordon equation, a fundamental model for wave propagation and energy dissipation. Using semigroup methods and spectral criteria, we derive explicit thresholds that determine when the system exhibits asymptotic stability and when it displays strong chaotic dynamics ...
Carlos Lizama   +2 more
wiley   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

open access: yesPrecision Medical Sciences, Volume 15, Issue 2, Page 147-159, June 2026.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim   +2 more
wiley   +1 more source

Advancing Heliophysics and Space Weather Modeling Through Open Science

open access: yesSpace Weather, Volume 24, Issue 6, June 2026.
Abstract We present a community‐wide effort to develop a strategy and action plan to advance heliophysics and space weather modeling through open science. While open science has the potential to enhance the quality and pace of scientific discovery, its application to scientific modeling requires more careful consideration regarding open data and open ...
C. Corti   +87 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

open access: yesCell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu   +16 more
wiley   +1 more source

Integrated Network Pharmacology and Machine Learning to Reveal the Mechanisms of Schisandrin A Against Triple‐Negative Breast Cancer

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT This study aimed to elucidate the mechanism of action of Schisandrin A in the intervention of triple‐negative breast cancer (TNBC). Through the application of network pharmacology and the integration of targets from multiple databases, the research identified 128 overlapping targets between Schisandrin A and TNBC.
Meng Xu   +6 more
wiley   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi   +4 more
wiley   +1 more source

Twisted ambidexterity in equivariant homotopy theory

open access: yesJournal of Topology, Volume 19, Issue 2, June 2026.
Abstract We develop the concept of twisted ambidexterity in a parametrized presentably symmetric monoidal ∞$\infty$‐category, which generalizes the notion of ambidexterity by Hopkins and Lurie and the Wirthmüller isomorphisms in equivariant stable homotopy theory, and is closely related to Costenoble–Waner duality.
Bastiaan Cnossen
wiley   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

open access: yesChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli   +13 more
wiley   +1 more source

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