Results 221 to 230 of about 327,247 (251)

Systems Toxicology Indicates AKT1/PTGS2‐Centered Neuroinflammatory‐Mitochondrial Crosstalk in Lidocaine Associated Neurotoxicity

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Lidocaine‐associated neurotoxicity is medicated by AKT1/PTG2 centered neuroinflammatory‐synaptic dysregulation coupled with mitochondrial impairment. This systems‐level insight provides a theoretical basis for improving the safety of pediatric lidocaine‐containing formulations.
Min Jiang, Liping Chen, Jingyi Deng, Hangyu Li, Yuqia Xie, Xueqin Huang, Weidong Liu, Suidong Ouyang   +7 more
wiley   +1 more source

Probing the Kitaev honeycomb model on a neutral-atom quantum computer. [PDF]

Nature
Evered SJ, Kalinowski M, Geim AA, Manovitz T, Bluvstein D, Li SH, Maskara N, Zhou H, Ebadi S, Xu M, Campo J, Cain M, Ostermann S, Yelin SF, Sachdev S, Greiner M, Vuletić V, Lukin MD.   +17 more
europepmc   +1 more source

Transcriptomic profiling reveals conserved stage‐associated programs across gastrointestinal adenocarcinomas

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Abstract Background Gastrointestinal (GI) adenocarcinomas exhibit substantial molecular heterogeneity despite their shared epithelial origin and anatomical continuity. Whether these anatomically distinct cancers share conserved transcriptomic programs associated with pathological stage remains unclear.
Wynston Jay Abenojar, Ron Jacob Avila, Po‐Wei Tsai, Lemmuel Tayo   +3 more
wiley   +1 more source

LASSBio-classFLOW: A Semiautomated KNIME Workflow for Classification Model Benchmarking and Virtual Screening. [PDF]

ACS Omega
Pinheiro PSM, da Silva JMA, de Jesus BDSM, Rodrigues DA, Lima LM.   +4 more
europepmc   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Predicting blood-brain barrier permeability of chemicals by machine learning modeling. [PDF]

NAM J
Chushak Y, Sterner TR, Clewell RA.
europepmc   +1 more source

Topology-Aware Deep Learning on Higher-Order Structures for Drug Response Prediction. [PDF]

Adv Sci (Weinh)
Shen C, Lin G, Hu CS, Wang Y.
europepmc   +1 more source

Uncovering Structure-Conductivity Relationships in Anion Exchange Membranes (AEMs) Using Interpretable Machine Learning. [PDF]

Membranes (Basel)
Naghshnejad P, Das D, Romagnoli JA, Kumar R, Chen J.   +4 more
europepmc   +1 more source

Shape modes of C P 1 vortices. [PDF]

Lett Math Phys
Gavrea N, Harland D, Speight M.
europepmc   +1 more source

Mapping the Evolutionary Landscape of Solid Tumor Immunotherapy: A Quarter-Century Bibliometric Analysis of the Title-Defined Core Literature (2000-2025). [PDF]

Int J Med Sci
Ozcelik EE, Akin G, Odabasi Bukun H, Sali M, Sahin AB, Deligonul A, Cubukcu E, Evrensel T.   +7 more
europepmc   +1 more source