A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy
The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling +9 more
wiley +1 more source
Real-time observation of topological defect dynamics mediating two-dimensional skyrmion lattice melting. [PDF]
Gruber R +10 more
europepmc +1 more source
Water‐Wave Pancharatnam‐Berry Phase Induced by 4D Spin‐Orbit State Evolution
The first observation of the Pancharatnam‐Berry (PB) phase in water waves is reported, revealing its extraordinary properties including unbounded phase values, spin‐momentum‐locked unidirectional channels, and a Poincaré hypersphere representation. These findings demonstrate the universality of the PB phase across different wave systems and in higher ...
Wanyue Xiao +3 more
wiley +1 more source
Evaluating topological and graph-theoretical approaches to extract complex multimodal brain connectivity patterns in multiple sclerosis. [PDF]
Lozano-Bagén T +11 more
europepmc +1 more source
BOCHNER PROBLEM ON A TOPOLOGICAL VECTOR SPACE WITH A QUASI-INVARIANT MEASURE-CHAPTER I
Yoshiaki Okazaki
openalex +2 more sources
Miniature Robotic Swimmer with Precise 2D Motion Control via Acoustic Vortex‐Induced Propulsion
In this work, a miniature robotic swimmer achieves precise 2D motion using sound waves with customized 3D‐printed lenses. Localized acoustic vortices drive both translation and rotation of the swimmer without mechanical parts. This contactless approach offers a novel route to controlled micro‐scale movement, with promising applications in biomedical ...
Chadi Ellouzi +6 more
wiley +1 more source
A microfluidics‐integrated chiral quasi‐BIC metachip is developed that generates strong broadband CD from 0.5–2.0 THz in aqueous environments. A UMAP algorithm processes the resulting multidimensional CD features for simultaneous biomolecular conformation identification and concentration quantification (0.05–0.3 mg dL−1).
Xinyue Liang +8 more
wiley +1 more source
Meta-Analysis and Topological Perturbation in Interactomic Network for Antiopioid Addiction Drug Repurposing. [PDF]
Zhang C +7 more
europepmc +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source

