Results 31 to 40 of about 4,059 (256)
Bio-inspired lattice structure optimisation with strain trajectory aligned trusses
Materials & Design, 2022 Lattice structures have great potential for lightweight additively manufactured parts. This paper presents a bio-inspired functionally graded lattice structure optimisation approach for compliance minimisation of statically loaded structures.
Stephen Daynes, Stefanie Feih
doaj +1 more source
Applied Sciences, 2021 Network intrusion detection systems that employ existing IP traceback (IPTBK) algorithms are generally unable to trace multiple attack sources. In these systems, the sampling mechanism only screens parts of the routing information, which leads to the ...
Hsiao-Chung Lin +3 more
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Phase field topology optimisation for 4D printing
ESAIM: Control, Optimisation and Calculus of Variations, 2023 This work concerns a structural topology optimisation problem for 4D printing based on the phase field approach. The concept of 4D printing as a targeted evolution of 3D printed structures can be realised in a two-step process. One first fabricates a 3D object with multi-material active composites and apply external loads in the programming stage. Then,
Garcke, Harald +3 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Minimum length scale constraints in multi-scale topology optimisation for additive manufacturing
Virtual and Physical Prototyping, 2019 This paper performs a combined numerical and experimental study to explore the role of minimum length scale constraints in multi-scale topology optimisation.
Jikai Liu +4 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Topology Optimisation of Wireless Sensor Networks
MATEC Web of Conferences, 2016 Wireless sensor networks are widely used in a variety of fields including industrial environments. In case of a clustered network the location of cluster head affects the reliability of the network operation.
Thike Aye Min +3 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Applied Sciences, 2020 The development of additive manufacturing allows the transformation of technological processes and the redesign of products. Among the most used methods to support additive manufacturing, the design can be optimised through the integration of topology ...
Enrico Dalpadulo +3 more
doaj +1 more source