Results 41 to 50 of about 2,266,507 (256)
Network Topology Optimization Based on Time-Triggered DIMA [PDF]
Xibei Gongye Daxue Xuebao, 2018 Distributed Integrated Modular Avionics System (DIMA) has attracted extensive attention in recent years, and the time-triggered Ethernet (TTE) supports the time triggering mechanism of DIMA system, so it has become the main protocol adopted by this ...
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Nihon Kikai Gakkai ronbunshu, 2023 In this paper, a concurrent optimization method of shape and topology for natural vibration design of shell structures is presented. The fundamental vibration eigenvalue is maximized under volume constraints for shape and topology optimization.
Masatoshi SHIMODA, Ryo TSUTSUMI
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Case study of natural convection topology optimization based on finite volume method
Case Studies in Thermal EngineeringTopology optimization is crucial for improving natural convection cooling devices. This study applies natural convection topology optimization to various engineering cases, including 2D, 3D, inclined, and inverted heat sink with various boundary ...
Honglei Liu +5 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Literature Reviews of Topology Optimal Design Methods and Applications in Magnetic Devices
EnergiesWith the evolution of magnetic devices toward structural innovation and high reliability, the traditional design methods, such as size optimization and shape optimization, are limited by preset structural forms, making it challenging to generate novel ...
Jiaqi Wu, Ziyan Ren, Dianhai Zhang
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A multi-material topology optimization with temperature-dependent thermoelastic properties
, 2021 This is a study on the development of a novel multi-material topology optimization scheme considering temperature-dependent thermoelastic properties for engineering structure design. Two cases, a three-point-bending beam under a uniform temperature field
Chen, Yuan +7 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
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