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Case study of natural convection topology optimization based on finite volume method
Case Studies in Thermal EngineeringTopology optimization is crucial for improving natural convection cooling devices. This study applies natural convection topology optimization to various engineering cases, including 2D, 3D, inclined, and inverted heat sink with various boundary ...
Honglei Liu +5 more
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Nihon Kikai Gakkai ronbunshu, 2023 In this paper, a concurrent optimization method of shape and topology for natural vibration design of shell structures is presented. The fundamental vibration eigenvalue is maximized under volume constraints for shape and topology optimization.
Masatoshi SHIMODA, Ryo TSUTSUMI
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Literature Reviews of Topology Optimal Design Methods and Applications in Magnetic Devices
EnergiesWith the evolution of magnetic devices toward structural innovation and high reliability, the traditional design methods, such as size optimization and shape optimization, are limited by preset structural forms, making it challenging to generate novel ...
Jiaqi Wu, Ziyan Ren, Dianhai Zhang
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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On the Topological Derivative in Shape Optimization [PDF]
SIAM Journal on Control and Optimization, 1999 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sokołowski, J., Żochowski, A.
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
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3D Topology Optimization of Fixed Offshore Structure and Experimental Validation
한국해양공학회지, 2020 In this study, we performed a three-dimensional (3D) topology optimization of a fixed offshore structure to enhance its structural stiffness. The proposed topology optimization is based on the solid isotropic material with penalization (SIMP) method ...
Hyun-Seok Kim +3 more
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Fatigue constrained topology optimization [PDF]
, 2014 We present a contribution to a relatively unexplored application of topology optimization: structural topology optimization with fatigue constraints. A probability based high-cycle fatigue analysis is combined with principal stress calculations in order ...
Torstenfelt, Bo, +5 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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