Results 51 to 60 of about 2,266,507 (256)

3D Topology Optimization of Fixed Offshore Structure and Experimental Validation

한국해양공학회지, 2020
In this study, we performed a three-dimensional (3D) topology optimization of a fixed offshore structure to enhance its structural stiffness. The proposed topology optimization is based on the solid isotropic material with penalization (SIMP) method ...
Hyun-Seok Kim, Hyun-Sung Kim, Byoungjae Park, Kangsu Lee   +3 more
doaj   +1 more source

Applications of Topology Optimization Techniques in Seismic Design of Structure

, 2012
During the last two decades, topology optimization techniques have been successfully applied to a wide range of problems including seismic design of structures.
Ghabraie, Kazem, Kazem Ghabraie
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Integrated optimal topology design and shape optimization using neural networks

, 2003
In this paper, neural network- and feature-based approaches are introduced to overcome current shortcomings in the automated integration of topology design and shape optimization.

core   +2 more sources

Fatigue Life and Lightweight Design of Demolition Robot Rotary Joint Based on Topology Optimization

Machines
As a critical component of demolition robots, the rotary joint supports the entire manipulator arm and operates under severe loading conditions, rendering it highly susceptible to fatigue failure.
Chentao Yao, Wendi Dong, Xingtao Zhang, Xizhong Cui, Zhuangwei Niu, Zheng-Yang Li, Jianwei Zhao, Dongjia Yan, Hongbo Li   +8 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Evolutionary approach for spatial architecture layout design enhanced by an agent-based topology finding system

Frontiers of Architectural Research, 2017
This paper presents a method for the automatic generation of a spatial architectural layout from a user-specified architectural program. The proposed approach binds a multi-agent topology finding system and an evolutionary optimization process.
Zifeng Guo, Biao Li
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

TOPOLOGY OPTIMIZATION METHOD BASED ON SIMP-MMC FOR STRUCTURE SIZE PRECISE CONTROL

Jixie qiangdu, 2022
With the development of structural topology optimization methods, some scholars had proposed strategies to integrate existing topology optimization methods to improve the manufacturability of topology optimization result.
ZHANG JunFeng, LIAO JingYu, LIU EnHai
doaj