Results 91 to 100 of about 9,436 (304)
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
Role-theoretic discourse analysis of German security policy: a case of German parliamentary debate on the mission in Afghanistan. [PDF]
Front Psychol, 2023 Ni X.
europepmc +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, EarlyView.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
A Topos Perspective on the Kochen-Specker Theorem: III. Von Neumann Algebras as the Base Category [PDF]
, 1999 John R. Hamilton +2 more
openalex +1 more source
, 2017 The modern semiclassical theory of a Bloch electron in a magnetic field now encompasses the orbital magnetic moment and the geometric phase. These two notions are encoded in the Bohr-Sommerfeld quantization condition as a phase ($ $) that is subleading in powers of the field; $ $ is measurable in the phase offset of the de Haas-van Alphen oscillation,
Alexandradinata, A. +3 more
openaire +2 more sources
The Limits of Law: Introducing a Rarely Frequented Topos [PDF]
, 2021 José Manuel Aroso Linhares +2 more
openalex +1 more source
Developmental Medicine &Child Neurology, EarlyView.Objetivos Identificar os instrumentos padronizados usados para avaliar aspectos de mobilidade em crianças e adolescentes com transtorno do espectro autista (TEA), analisar a qualidade de suas propriedades psicométricas e seu nível de evidência, e desenvolver um mapa de decisão clínica para esses instrumentos.
Arthur Felipe Barroso de Lima +4 more
wiley +1 more source
The Island Topos: From Paradise to Prison
American and British Studies Annual, 2017 This article deals with the transformation of the island topos. The island is frequently depicted as a paradise and prison in English literature and the article elaborates on the transformation of the two topoi.
Martin Mareš
doaj
The FEBS Journal, EarlyView.midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen +6 more
wiley +1 more source
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
The FEBS Journal, EarlyView.PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source