Results 181 to 190 of about 152,913 (283)

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

Experimental localization of metal-binding sites reveals the role of metal ions in type II DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A
Wang B, Najmudin S, Pan XS, Mykhaylyk V, Orr C, Wagner A, Govada L, Chayen NE, Fisher LM, Sanderson MR.   +9 more
europepmc   +1 more source

Mutations in Components of the TREX‐2 Complex Result in Misexpression of the Kelch‐Domain F‐Box Protein KFB39 Promoter in Arabidopsis thaliana

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Arabidopsis thaliana gene At2g44130 encodes a Kelch‐like domain F‐box protein designated KFB39 and was previously shown to be specifically expressed on exposure to the oxylipin cis‐jasmone. In order to better understand the regulation of At2g44130, a forward genetic screen was carried out to identify mutants in which a promoter‐GUS fusion was ...
Michaela C. Matthes, Smita Kurup, John A. Pickett, Johnathan A. Napier   +3 more
wiley   +1 more source

Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq. [PDF]

Nucleic Acids Res
Morgan IL, McKie SJ, Kim R, Seol Y, Xu J, Harami GM, Maxwell A, Neuman KC.   +7 more
europepmc   +1 more source

A notion of homotopy for the effective topos

Mathematical Structures in Computer Science, 2014
J. V. Oosten
semanticscholar   +1 more source

Probabilistic Clustering Using Multivariate Growth Mixture Model in Clinical Settings—A Scleroderma Example

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Background Scleroderma (systemic sclerosis; SSc) is a chronic autoimmune disease known for wide heterogeneity in patients' disease progression in multiple organ systems. Our goal is to guide clinical care by real‐time classification of patients into clinically interpretable subpopulations based on their baseline characteristics and the ...
Ji Soo Kim, Yizhen Xu, Rachel S. Wallwork, Laura K. Hummers, Ami A. Shah, Scott L. Zeger   +5 more
wiley   +1 more source

Phylogenetic distribution of DNA topoisomerase VI and its distinction from SPO11. [PDF]

NAR Genom Bioinform
Allen AMB, Maxwell A.
europepmc   +1 more source

Understanding Multiscale Hydrological Interactions From Spectral Perspective: A Large Sample Investigation Across the United States

Water Resources Research, Volume 62, Issue 2, February 2026.
Abstract Hydrological processes involve multi‐time scale interactions among different variables, and the interactions are driven, in part, by climate and landscape factors. Knowledge on the relationships of hydrological interactions with climate and landscape factors is crucial for modeling the hydrological processes, including the model structure ...
Hanxu Liang, Dedi Liu, Wensheng Wang, Feng Yue, Jiayu Zhang   +4 more
wiley   +1 more source

DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. [PDF]

Bioessays, 2021
McKie SJ, Neuman KC, Maxwell A.
europepmc   +1 more source

Analysis of the Dynamics of Clinical Parameters and Serum Angiogenic Factors in Systemic Sclerosis Patients Undergoing Tocilizumab Treatment

Experimental Dermatology, Volume 35, Issue 2, February 2026.
This study demonstrates that tocilizumab (TCZ) treatment promotes microvascular recovery in systemic sclerosis (SSc), as evidenced by increased capillary density and that this improvement in vasculopathy is closely associated with enhanced pulmonary function.
Yuichiro Segawa, Takehiro Takahashi, Takuya Takahashi, Kenta Oka, Yumi Kambayashi, Toshiya Takahashi, Yoshihide Asano   +6 more
wiley   +1 more source